Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
J Colloid Interface Sci. 2023 Aug;643:183-195. doi: 10.1016/j.jcis.2023.04.002. Epub 2023 Apr 7.
Graphitic carbon nitride (g-CN) has received much attention as a metal-free polymeric two-dimensional photocatalyst for antibiotic-free antibacterial application. However, the weak photocatalytic antibacterial activity of pure g-CN stimulated by visible light limits its applications. Herein, g-CN is modified with Zinc (II) meso-tetrakis (4-carboxyphenyl) porphyrin (ZnTCPP) by amidation reaction to enhance the utilization of visible light and reduce the recombination of electron-hole pairs. The composite (ZP/CN) is used to treat bacterial infection under visible light irradiation with a high efficacy of 99.99% within 10 min due to the enhanced photocatalytic activity. Ultraviolet photoelectron spectroscopy and density flooding theory calculations indicate the excellent electrical conductivity between the interface of ZnTCPP and g-CN. The formed built-in electric field is responsible for the high visible photocatalytic performance of ZP/CN. In vitro and in vivo tests have demonstrated that ZP/CN not only possesses excellent antibacterial activity upon visible light irradiation, but also facilitates the angiogenesis. In addition, ZP/CN also suppresses the inflammatory response. Therefore, this inorganic-organic material can serve as a promising platform for effective healing of bacteria-infected wounds.
石墨相氮化碳（g-CN）作为一种无金属的二维聚合物光催化剂，在无抗生素抗菌应用方面受到了广泛关注。然而，纯 g-CN 受可见光激发的弱光催化抗菌活性限制了其应用。在此，通过酰胺化反应将 g-CN 与锌（II）meso-四（4-羧基苯基）卟啉（ZnTCPP）进行修饰，以增强可见光的利用并减少电子-空穴对的复合。由于光催化活性的提高，复合（ZP/CN）在可见光照射下用于治疗细菌感染，在 10 分钟内的高效性达到 99.99%。紫外光电子能谱和密度泛函理论计算表明 ZnTCPP 和 g-CN 界面之间具有优异的导电性。形成的内置电场是 ZP/CN 具有高光催化性能的原因。体外和体内实验表明，ZP/CN 不仅在可见光照射下具有优异的抗菌活性，而且有利于血管生成。此外，ZP/CN 还抑制了炎症反应。因此，这种无机-有机材料可以作为一种有前途的平台，用于有效治疗细菌感染的伤口。
