Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, P. R. China.
National Graphene Products Quality Inspection and Testing Center (Jiangsu), Special Equipment Safety Supervision Inspection Institute of Jiangsu Province, Yanxin Road 330, Wuxi, 214174, P. R. China.
Small. 2022 Jul;18(26):e2200857. doi: 10.1002/smll.202200857. Epub 2022 Jun 3.
Light-assisted antibacterial therapy is a promising alternative to antibiotic therapy due to the high antibacterial efficacy without bacterial resistance. Recent research has mainly focused on the use of near-infrared light irradiation to kill bacteria by taking advantage of the synergistic effects rendered by hyperthermia and radical oxygen species. However, photocatalytic antibacterial therapy excited by visible light is more convenient and practical, especially for wounds. Herein, a visible light responsive organic-inorganic hybrid of ZnTCPP/Ti C T is designed and fabricated to treat bacterial infection with antibacterial efficiency of 99.86% and 99.92% within 10 min against Staphylococcus aureus and Escherichia coli, respectively. The porphyrin-metal complex, ZnTCPP, is assembled on the surface of Ti C T MXene to capture bacteria electrostatically and the Schottky junction formed between Ti C T and ZnTCPP promotes visible light utilization, accelerates charge separation, and enhances the mobility of photogenerated charges, and finally increases the photocatalytic activity. As a result of the excellent bacteria capturing ability and photocatalytic antibacterial effects, ZnTCPP/Ti C T exposed to visible light has excellent antibacterial properties in vitro and in vivo. Therefore, organic-inorganic materials that have been demonstrated to possess good biocompatibility and enhance wound healing have large potential in bio-photocatalysis, antibacterial therapy, as well as antibiotics-free treatment of wounds.
光辅助抗菌疗法由于其高效的抗菌效果而没有细菌耐药性，是抗生素治疗的一种有前途的替代方法。最近的研究主要集中在利用近红外光照射通过热疗和自由基协同作用来杀死细菌。然而，可见光激发的光催化抗菌疗法更方便实用，特别是对于伤口。本文设计并制备了一种可见响应的 ZnTCPP/TiC T 有机-无机杂化材料，对金黄色葡萄球菌和大肠杆菌的抗菌效率分别达到 99.86%和 99.92%，在 10 分钟内即可杀灭细菌。卟啉-金属配合物 ZnTCPP 静电组装在 TiC T MXene 表面，捕获细菌，TiC T 和 ZnTCPP 之间形成的肖特基结促进可见光的利用，加速电荷分离，增强光生载流子的迁移率，最终提高光催化活性。由于具有优异的细菌捕获能力和光催化抗菌效果，暴露在可见光下的 ZnTCPP/TiC T 在体外和体内均具有优异的抗菌性能。因此，具有良好生物相容性和促进伤口愈合能力的有机-无机材料在生物光催化、抗菌治疗以及无抗生素治疗伤口方面具有巨大的潜力。
