Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Oncode Institute, the Netherlands.
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Oncode Institute, the Netherlands; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Houtlaan 4, 6525 XZ Nijmegen, the Netherlands.
Cell Rep. 2023 Apr 25;42(4):112248. doi: 10.1016/j.celrep.2023.112248. Epub 2023 Apr 13.
During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.
在哺乳动物发育的早期阶段，亲代基因组的表观遗传状态被完全重编程，从而产生全能胚胎。这种重塑的一个重要方面涉及异染色质和基因组的空间组织。虽然异染色质和基因组组织在多能性和体细胞系统中紧密相关，但在全能胚胎中它们之间的关系知之甚少。在这篇综述中，我们总结了目前关于这两个调控层重编程的知识。此外，我们还讨论了它们之间关系的现有证据，并将其置于其他系统的研究结果背景下。
