Saleh Jasmine S, Whittington Carli P, Bresler Scott C, Patel Rajiv M
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
Hum Pathol. 2023 Oct;140:53-65. doi: 10.1016/j.humpath.2023.04.004. Epub 2023 Apr 12.
Cutaneous vascular tumors constitute a heterogeneous group of entities that share overlapping morphologic and immunohistochemical features, which can be diagnostically challenging for pathologists and dermatopathologists. Our understanding and knowledge of vascular neoplasms have improved over time, resulting in both a refinement of their classification by the International Society for the Study of Vascular Anomalies (ISSVA) and an improvement in the accurate diagnosis and clinical management of vascular neoplasms. This review article aims to summarize the updated clinical, histopathological, and immunohistochemical characteristics of cutaneous vascular tumors, as well as to highlight their associated genetic mutations. Such entities include infantile hemangioma, congenital hemangioma, tufted angioma, spindle cell hemangioma, epithelioid hemangioma, pyogenic granuloma, Kaposiform hemangioendothelioma, retiform hemangioendothelioma, pseudomyogenic hemangioendothelioma, Kaposi sarcoma, angiosarcoma, and epithelioid hemangioendothelioma.
皮肤血管肿瘤是一组异质性疾病，它们具有重叠的形态学和免疫组化特征，这对病理学家和皮肤病理学家来说在诊断上具有挑战性。随着时间的推移，我们对血管肿瘤的理解和认识有所提高，这导致国际血管异常研究学会（ISSVA）对其分类进行了细化，同时血管肿瘤的准确诊断和临床管理也得到了改善。这篇综述文章旨在总结皮肤血管肿瘤最新的临床、组织病理学和免疫组化特征，并强调其相关的基因突变。这些疾病包括婴儿血管瘤、先天性血管瘤、丛状血管瘤、梭形细胞血管瘤、上皮样血管瘤、化脓性肉芽肿、卡波西样血管内皮瘤、网状血管内皮瘤、假肌源性血管内皮瘤、卡波西肉瘤、血管肉瘤和上皮样血管内皮瘤。
