Department of Physiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, the Netherlands.
Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany.
Atherosclerosis. 2023 Jun;374:99-106. doi: 10.1016/j.atherosclerosis.2023.03.019. Epub 2023 Apr 5.
Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
动脉粥样硬化和许多其他心血管疾病是随年龄增长而发展的。内皮细胞在动脉粥样硬化的发展中起着重要作用。已知非编码 RNA，如 microRNAs 和长非编码 RNA，在内皮功能中起重要作用，并与疾病进展有关。在这里，我们总结了几种已知在内皮老化时表达发生改变的 microRNAs 和长非编码 RNA，并讨论了它们在内皮细胞功能和衰老中的作用。这些过程有助于衰老诱导的动脉粥样硬化发展，通过靶向控制内皮细胞功能和衰老的非编码 RNA，动脉粥样硬化可能会得到缓解。
