Pediatric Pulmonary Unit and Cystic fibrosis Center, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Pediatric Pulmonary Unit and Cystic fibrosis Center, Hadassah Medical Center, Jerusalem, Israel.
J Cyst Fibros. 2023 Jul;22(4):772-776. doi: 10.1016/j.jcf.2023.04.004. Epub 2023 Apr 13.
The hallmarks of Cystic fibrosis (CF), chronic infection and inflammation, require intensive daily treatment to maintain and improve quality of life and outcome. The incidence of Attention Deficit/Hyperactivity Disorder (ADHD) is increased in chronic inflammatory diseases. Previous studies suggested that the prevalence of ADHD in people with CF (pwCF) is higher than in the general population. The objective of this study was to evaluate the association between ADHD symptoms and parameters of CF disease severity, measured by demographic and clinical data.
Based on our previous study, the results of ADHD questionnaires and the MOXOCPT (continuous performance task) from 143 pwCF (7-68 years old) were analyzed and linked to patient data such as forced expiratory volume in 1 second (FEV)%predicted, body mass index (BMI), number of pulmonary exacerbations, days of antibiotic (Abx) treatment and serum inflammatory markers.
A positive correlation between FEV and ADHD questionnaire's score (p = 0.046) was observed in the children's group. Furthermore, BMI, white blood cells (WBC) count, and days of Abx treatment showed a positive correlation with some of the MOXOCPT parameters.
There is an association between ADHD symptoms and some parameters of CF disease severity. These results highlight the need for an early diagnosis of ADHD in pwCF, which have the potential to improve their ability to deal with the burden of their disease and consequently their quality of life. Additional research is needed to understand the full spectrum of ADHD pathophysiology and the relationship with chronic inflammatory diseases such as CF.
囊性纤维化 (CF) 的标志是慢性感染和炎症，需要进行密集的日常治疗，以维持和改善生活质量和预后。注意力缺陷多动障碍 (ADHD) 在慢性炎症性疾病中的发病率增加。先前的研究表明，CF 患者 (pwCF) 中 ADHD 的患病率高于普通人群。本研究旨在评估 ADHD 症状与 CF 疾病严重程度参数之间的关联，这些参数通过人口统计学和临床数据进行测量。
基于我们之前的研究，分析了 143 名 pwCF（7-68 岁）的 ADHD 问卷和 MOXOCPT（连续性能任务）的结果，并将其与患者数据（如 1 秒用力呼气量百分比预测值（FEV%predicted）、体重指数（BMI）、肺部加重发作次数、抗生素（Abx）治疗天数和血清炎症标志物）相关联。
在儿童组中观察到 FEV 与 ADHD 问卷评分之间存在正相关（p=0.046）。此外，BMI、白细胞计数（WBC）和 Abx 治疗天数与 MOXOCPT 的一些参数呈正相关。
ADHD 症状与 CF 疾病严重程度的某些参数之间存在关联。这些结果强调了在 pwCF 中早期诊断 ADHD 的必要性，这有可能提高他们应对疾病负担的能力，从而提高他们的生活质量。需要进一步研究以了解 ADHD 病理生理学的全貌以及与 CF 等慢性炎症性疾病的关系。
