Lee R G
Am J Clin Pathol. 1986 May;85(5):629-32. doi: 10.1093/ajcp/85.5.629.
Three cases of the unusual esophageal adenoma are described. The patients included two men and one woman, with a mean age of 61 years, who presented with dysphagia or heartburn. Histologically, the esophageal adenomas were composed of dysplastic epithelium in a polypoid configuration, similar to adenomas elsewhere in the gastrointestinal tract. All three adenomas arose within Barrett's esophagus (columnar epithelium-lined distal esophagus), and dysplastic Barrett's mucosa was found in the adjacent mucosa of each case. Critical review of the literature identified three additional cases; similar clinicopathologic features were described. Esophageal adenomas are a complication of Barrett's esophagus and are best considered as macroscopic variants of epithelial dysplasia rather than as isolated adenomatous polyps. As such, they likely represent premalignant lesions.
本文描述了三例罕见的食管腺瘤病例。患者包括两名男性和一名女性，平均年龄61岁，表现为吞咽困难或烧心症状。组织学上，食管腺瘤由呈息肉状结构的发育异常上皮组成，类似于胃肠道其他部位的腺瘤。所有三例腺瘤均发生于巴雷特食管（柱状上皮衬里的食管远端），且在每例病例的相邻黏膜中均发现发育异常的巴雷特黏膜。对文献的严格审查又发现了另外三例病例；并描述了相似的临床病理特征。食管腺瘤是巴雷特食管的一种并发症，最好将其视为上皮发育异常的宏观变体，而非孤立的腺瘤性息肉。因此，它们可能代表癌前病变。
