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升主动脉瘤在 A 型和 B 型夹层时的大小。

Aortic Size at the Time of Type A and Type B Dissections.

机构信息

Aortic Institute at Yale-New Haven Hospital, New Haven, Connecticut.

Aortic Institute at Yale-New Haven Hospital, New Haven, Connecticut.

出版信息

Ann Thorac Surg. 2023 Aug;116(2):262-268. doi: 10.1016/j.athoracsur.2023.03.037. Epub 2023 Apr 14.

DOI:10.1016/j.athoracsur.2023.03.037
PMID:37062339
Abstract

BACKGROUND

Aortic diameter at time of dissection remains an indispensable risk-determining characteristic for prophylactic repair of thoracic aortic aneurysms. Histograms of aortic size at the time of dissection have the potential to shed more light on this relationship.

METHODS

Size of the thoracic aorta at the time of dissection was determined from imaging of 407 naturally occurring, acute, flap-type ascending or descending aortic dissections treated at 1 institution (1990-2022). Histograms were constructed to depict aortic size at the time of dissection. Data were analyzed by logistic regression.

RESULTS

There were 170 (69.11%) of 246 type A dissections (median, 5.07 cm; interquartile range, 4.60-5.67 cm) and 130 (80.75%) of 161 type B dissections (median, 4.2 cm; interquartile range, 3.60-4.87 cm) that occurred at diameters <5.5 cm. By unadjusted regression, factors associated with significantly increased odds of type A dissection at diameters <5.5 cm were female sex (odds ratio [OR], 2.06; P = .023), hypertension (OR, 1.82; P = .036), and smoking (OR, 1.92; P = .029). Patients with bicuspid aortic valve had significantly decreased odds of type A dissection at diameters <5.5 cm (OR, 0.3; P = .047). The recent "left shift" to 5.0 cm in the criterion for ascending aortic intervention could prevent an additional 29.3% of type A dissections.

CONCLUSIONS

Aortic diameter at the time of type A dissection is consistent with the new guidelines that recommend surgical intervention at 5.0 cm. Type B dissection occurs at small sizes and cannot be prevented with a size criterion.

摘要

背景

在夹层发生时的主动脉直径仍然是决定胸主动脉瘤预防性修复的不可或缺的风险特征。夹层发生时主动脉大小的直方图有可能进一步阐明这种关系。

方法

在一家机构(1990 年至 2022 年)治疗的 407 例自然发生的急性夹层型升主动脉或降主动脉夹层中,从影像学上确定夹层发生时的胸主动脉大小。构建直方图以描绘夹层发生时的主动脉大小。通过逻辑回归分析数据。

结果

170 例(69.11%)246 例 A 型夹层(中位数为 5.07cm;四分位间距为 4.60-5.67cm)和 130 例(80.75%)161 例 B 型夹层(中位数为 4.2cm;四分位间距为 3.60-4.87cm)发生在<5.5cm 的直径处。未经调整的回归分析显示,与直径<5.5cm 的 A 型夹层显著增加的可能性相关的因素是女性(比值比 [OR],2.06;P=.023)、高血压(OR,1.82;P=.036)和吸烟(OR,1.92;P=.029)。二叶式主动脉瓣患者在直径<5.5cm 的 A 型夹层发生的可能性显著降低(OR,0.3;P=.047)。升主动脉介入标准最近向 5.0cm 的“左移”可能会预防另外 29.3%的 A 型夹层。

结论

A 型夹层发生时的主动脉直径与建议在 5.0cm 时进行手术干预的新指南一致。B 型夹层发生在小尺寸,不能用尺寸标准预防。

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