Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France; Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, India.
Research Institute of McGill University Health Centre, Translational Program in Respiratory Diseases and Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
J Allergy Clin Immunol Pract. 2023 Jun;11(6):1688-1697. doi: 10.1016/j.jaip.2023.04.002. Epub 2023 Apr 14.
Intravenous immunoglobulin (IVIG) is the mainstay of therapy for humoral immune deficiencies and numerous inflammatory disorders. Although the use of IVIG may be supplanted by several targeted therapies to cytokines, the ability of polyclonal normal IgG to act as an effector molecule as well as a regulatory molecule is a clear example of the polyfunctionality of IVIG. This article will address the mechanism of action of IVIG in a number of important conditions that are otherwise resistant to treatment. In this commentary, we will highlight mechanistic studies that shed light on the action of IVIG. This will be approached by identifying effects that are both common and disease-specific, targeting actions that have been demonstrated on cells and processes that represent both innate and adaptive immune responses.
静脉注射免疫球蛋白（IVIG）是治疗体液免疫缺陷和多种炎症性疾病的主要方法。尽管针对细胞因子的几种靶向治疗可能会取代 IVIG 的使用，但多克隆正常 IgG 作为效应分子和调节分子的能力清楚地说明了 IVIG 的多功能性。本文将讨论 IVIG 在一些对治疗有抵抗力的重要疾病中的作用机制。在这篇评论中，我们将强调阐明 IVIG 作用的机制研究。通过确定在代表固有和适应性免疫反应的细胞和过程上具有共同和疾病特异性靶向作用的效果来实现这一点。
