Gluckman J C, Jacob N, Beaufils H, Baumelou A, Salah H, German A, Legrain M
Nephron. 1978;22(1-3):138-45. doi: 10.1159/000181435.
Sera from 168 patients with various types of chronic glomerulonephritis (GN) were assayed for immune complexes (IC) by two independent methods, a modification of the PEG precipitation test (PEG) and the inhibition of complement-dependent lymphocyte rosette formation (RI). Both assays had different reactivities, the RI being more sensitive than the PEG test. Higher percentages of positivity of these tests were observed in the GN groups than in normal controls. However serial measurements demonstrated that IC were present only intermittently in most instances. The presence of IC correlated with disease activity in patients with focal glomerulosclerosis membranous GN and membranoproliferative GN, while in lupus erythematosus it reflected the effects of different treatment regimens although it had no relationship with clinical symptoms. Nevertheless, our results suggest that these tests are of little help to the clinician to appreciate disease activity and monitor therapy in individual GN patients.
采用两种独立方法，即聚乙二醇沉淀试验（PEG）的改良方法和补体依赖性淋巴细胞玫瑰花结形成抑制试验（RI），对168例不同类型慢性肾小球肾炎（GN）患者的血清进行免疫复合物（IC）检测。两种检测方法的反应性不同，RI比PEG试验更敏感。GN组这些检测的阳性率高于正常对照组。然而，连续检测表明，在大多数情况下，IC仅间歇性存在。IC的存在与局灶性肾小球硬化、膜性GN和膜增生性GN患者的疾病活动相关，而在红斑狼疮中，它反映了不同治疗方案的效果，尽管与临床症状无关。尽管如此，我们的结果表明，这些检测对临床医生评估个体GN患者的疾病活动和监测治疗帮助不大。
