Lankisch P G, Koop H, Otto J
Am J Gastroenterol. 1986 May;81(5):365-8.
Using an inhibitor method, fasting levels of pancreatic isoamylase were measured in 46 healthy controls and in 218 patients undergoing a secretin-pancreozymin test for diagnostic purposes, and compared with immunoreactive trypsin (IRT). Exocrine pancreatic insufficiency was found in 82 of the patients. The specificity of both enzymes was high in patients with nonpancreatic diseases (pancreatic isoamylase: 98.5%, IRT: 96.3%). No patient with nonpancreatogenic steatorrhea had a low serum enzyme value. Sensitivity was, unfortunately, low in patients with exocrine pancreatic insufficiency (pancreatic isoamylase: 45.1%, IRT: 41.5%) and increased only slightly when patients after an acute attack of the disease, or patients with pseudocysts or older than 60 were excluded (pancreatic isoamylase: 67.9%, IRT: 58.5%). Although highly specific, pancreatic isoamylase measurement is not sensitive enough to be used as a screening test for exocrine pancreatic insufficiency but may be used to determine the etiology of steatorrhea.
采用抑制剂法，对46名健康对照者以及218名因诊断目的而接受促胰液素-胰酶泌素试验的患者测量了空腹胰腺异淀粉酶水平，并与免疫反应性胰蛋白酶（IRT）进行比较。在这些患者中，发现82例存在外分泌性胰腺功能不全。在患有非胰腺疾病的患者中，这两种酶的特异性都很高（胰腺异淀粉酶：98.5%，IRT：96.3%）。没有非胰腺源性脂肪泻患者的血清酶值偏低。遗憾的是，外分泌性胰腺功能不全患者中这两种酶的敏感性较低（胰腺异淀粉酶：45.1%，IRT：41.5%），当排除疾病急性发作后的患者、患有假性囊肿的患者或60岁以上的患者后，敏感性仅略有提高（胰腺异淀粉酶：67.9%，IRT：58.5%）。尽管胰腺异淀粉酶测量具有高度特异性，但作为外分泌性胰腺功能不全的筛查试验，其敏感性不足够，但可用于确定脂肪泻的病因。
