Malfertheiner P, Bieger W, Trischler G, Ditschuneit H
Dtsch Med Wochenschr. 1982 Jun 4;107(22):849-53. doi: 10.1055/s-2008-1070032.
The pancreatic serum evocation test with secretin has regained importance now that it is possible to determine immunoreactive trypsin and pancreatic isoamylase. After secretin stimulation there was a significant abnormal increase in serum trypsin (p less than 0.01) in 34 patients with proven chronic pancreatitis associated with mild to moderate dysfunction (groups I-II), no rise if there was marked insufficiency (group III). Patients with steatorrhoea and obstruction in the region of the head of the pancreas formed a special group because, contrary to other patients in groups III, they had marked serum enzyme rise after secretin. In 24 control subjects with a normal pancreas there was no significant change in basal pancreatic serum enzyme levels with secretin stimulation. Trypsin and amylase reaction patterns differed during secretin stimulation, with a rise in the amylase occurring at the expense of pancreas isoamylase.
鉴于现在能够测定免疫反应性胰蛋白酶和胰腺异淀粉酶，用促胰液素进行的胰腺血清激发试验再次变得重要起来。在34例经证实患有与轻至中度功能障碍相关的慢性胰腺炎患者（I - II组）中，促胰液素刺激后血清胰蛋白酶显著异常升高（p小于0.01）；如果存在明显功能不全（III组）则无升高。伴有脂肪泻和胰头区域梗阻的患者形成一个特殊组，因为与III组的其他患者相反，他们在促胰液素刺激后血清酶显著升高。在24例胰腺正常的对照受试者中，促胰液素刺激后基础胰腺血清酶水平无显著变化。在促胰液素刺激期间，胰蛋白酶和淀粉酶的反应模式不同，淀粉酶升高是以胰腺异淀粉酶为代价的。
