Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Int J Biol Sci. 2023 Mar 27;19(6):1955-1967. doi: 10.7150/ijbs.80401. eCollection 2023.
Follicular lymphoma (FL) is the most common indolent lymphoma originating from germinal center B cells. FL represents a clinically and biologically heterogeneous disease. Most patients have favorable outcomes, but a subset of patients experiences early progression or transformation and has a poor prognosis. Abnormalities in FL cells and tumor microenvironment have been revealed using multi-omics techniques, including genomic, epigenomic, transcriptomic and proteomic analysis. Recurrent somatic gene aberrations mainly involve epigenetic modifiers, transcription factors, oncogenic pathways and microenvironment modulators. Single-cell transcriptomic analysis show marked inter- and intra-patient FL subclone heterogeneity. In addition, a comprehensive profile of microenvironmental components is provided, unveiling the crosstalk between tumor and microenvironment that induce FL progression and facilitate immune escape. Together, these studies provide insights into the mechanisms and biomarkers of high-risk FL populations, as well as the potential targeted and immunotherapy options. Future research should focus on integrating multi-omics aberrations to optimize therapeutic strategies in FL.
滤泡性淋巴瘤（FL）是最常见的起源于生发中心 B 细胞的惰性淋巴瘤。FL 是一种临床表现和生物学特征均具有异质性的疾病。大多数患者预后良好，但有一部分患者早期进展或转化，预后不良。应用包括基因组、表观基因组、转录组和蛋白质组分析在内的多组学技术，揭示了 FL 细胞和肿瘤微环境的异常。复发性体细胞基因异常主要涉及表观遗传修饰物、转录因子、致癌途径和微环境调节剂。单细胞转录组分析显示出明显的患者间和患者内 FL 亚克隆异质性。此外，还提供了微环境成分的综合图谱，揭示了肿瘤与微环境之间的相互作用，这些相互作用导致 FL 的进展并促进免疫逃逸。综上所述，这些研究为高危 FL 人群的发病机制和生物标志物，以及潜在的靶向和免疫治疗选择提供了深入的见解。未来的研究应集中于整合多组学异常，以优化 FL 的治疗策略。
