Almajidi Yasir Qasim, Ubaidullah Mohd, Pandit Bidhan, Kareem A K, Romero-Parra Rosario Mireya, Bobirjon Adizov, Kadhum Wesam R, Al-Erjan Amran M, Abosaooda Munther, Mahmoud Aisha Kamal
Department of Pharmacy (Pharmaceutics), Baghdad College of Medical Sciences Baghdad Iraq.
Department of Chemistry, College of Science, King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia
RSC Adv. 2023 Apr 14;13(17):11393-11405. doi: 10.1039/d3ra01720f. eCollection 2023 Apr 11.
In the current body of research, a very quick and effectual procedure for the synthesis of pyrido[2,3-:6,5-']dipyrimidines has been developed. This method is accomplished through the one-pot multi-component reaction of 2-thiobarbituric acid, NHOAc and aldehydes utilizing Ni-TMEDA@βSiO@αSiO@FeO as a novel mesoporous nanomagnetic catalyst at room temperature. This protocol is one of the few reports of the preparation of these derivatives without the use of conventional heating as well as energies such as microwave and ultrasound radiation. The characterization of the prepared catalyst was well accomplished by different techniques such as FT-IR, ICP-OES, SEM, TEM, BET, XRD, VSM, TGA, EDX and Elemental mapping. This organometallic catalyst was reusable for seven times with negligible decrement in its catalytic performance. In addition, all of the products were produced with high TON and TOF values, which demonstrates that our catalyst has a very high level of activity in the preparation of pyrido[2,3-:6,5-']dipyrimidines.
在当前的研究中，已开发出一种非常快速且有效的合成吡啶并[2,3 - :6,5 - ']二嘧啶的方法。该方法是在室温下，利用Ni - TMEDA@βSiO@αSiO@FeO作为新型介孔纳米磁性催化剂，通过2 - 硫代巴比妥酸、NHOAc和醛的一锅多组分反应来完成的。该方案是少数几篇不使用传统加热以及微波和超声辐射等能量来制备这些衍生物的报道之一。通过FT - IR、ICP - OES、SEM、TEM、BET、XRD、VSM、TGA、EDX和元素映射等不同技术对制备的催化剂进行了很好的表征。这种有机金属催化剂可重复使用七次，其催化性能的下降可忽略不计。此外，所有产物的TON和TOF值都很高，这表明我们的催化剂在吡啶并[2,3 - :6,5 - ']二嘧啶的制备中具有非常高的活性水平。
