Naeimi Hossein, Didar Asieh, Rashid Zahra, Zahraie Zohreh
Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, Kashan, Iran.
Young Researchers and Elite Club, Central Branch, Islamic Azad University, Tehran, Iran.
J Antibiot (Tokyo). 2017 Jul;70(7):845-852. doi: 10.1038/ja.2017.47. Epub 2017 Apr 26.
In this study, the one-pot four-component reaction of aromatic aldehyde, 2-thiobarbituric acid, ammonium acetate in the presence of a catalytic amount of [H-NMP][HSO] under ultrasonic irradiation in water is reported. In the present procedure, the pyrido[2,3-d:6,5-d']dipyrimidine derivatives were purely produced as valuable products. The process proved to be simple, environmentally friendly, efficient and high to excellent yielding. Moreover, some of the synthetic compounds were investigated and revealed important antimicrobial activity of prepared products.
本研究报道了在水相中超声辐射下，芳醛、2-硫代巴比妥酸、醋酸铵在催化量的[H-NMP][HSO]存在下的一锅四组分反应。在此过程中，吡啶并[2,3-d:6,5-d']二嘧啶衍生物作为有价值的产物被纯合成出来。该方法被证明是简单、环保、高效且产率高至优异的。此外，对一些合成化合物进行了研究，结果表明所制备的产物具有重要的抗菌活性。
