Han Sileny N, Verheecke Magali, Vandenbroucke Tineke, Gziri Mina Mhallem, Van Calsteren Kristel, Amant Frédéric
Gynecologic Oncology, University Hospitals Leuven, and Division of Oncology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium,
Curr Oncol Rep. 2014 Dec;16(12):415. doi: 10.1007/s11912-014-0415-z.
The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually impossible, and current evidence is mainly based on small case series and expert opinion. Individualization of treatment is necessary and based on tumor type, stage, and gestational age at time of diagnosis. Termination of pregnancy is not necessary in most cases. Surgery and chemotherapy (second trimester and onwards) are possible types of treatment during pregnancy. Radiotherapy of the pelvic area is not compatible with an ongoing pregnancy. This article discusses the current recommendations for the management of gynecological malignancies (cervical, ovarian, and vulvar cancers) during pregnancy.
孕期诊断出妇科恶性肿瘤虽罕见但并不鲜见。孕期进行癌症治疗是可行的，但母体和胎儿的利益都需得到尊重。不同的治疗方案可能合理，建议采用多学科治疗。临床试验几乎不可能进行，目前的证据主要基于小病例系列和专家意见。治疗必须个体化，依据肿瘤类型、分期以及诊断时的孕周。多数情况下无需终止妊娠。手术和化疗（孕中期及以后）是孕期可能的治疗方式。盆腔区域的放疗与继续妊娠不相容。本文讨论了孕期妇科恶性肿瘤（宫颈癌、卵巢癌和外阴癌）管理的当前建议。
