Wang Huan, Zhang Quan, Liu Qin, Wu Xian, Ma Ke
Department of Infectious Diseases, The Affiliated Hospital, Guizhou Medical University, Guiyang, China.
Front Oncol. 2023 Mar 31;13:1145540. doi: 10.3389/fonc.2023.1145540. eCollection 2023.
The 5th edition of World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) is characterized by its hierarchical system for classification and novel entities/types. Considering the significant discrepancy in clinical manifestations and prognosis, fluid overload-associated large B-cell lymphoma (FOALBCL) has been a new addition to the WHO-HAEM5, being distinct from the traditional diagnosis of primary effusion lymphoma. In this manuscript, we report a patient who was diagnosed with FOALBCL that a novel entity introduced in the WHO-HAEM5. It is an instance of a successful application of the updated WHO-HAEM5 and indicates that the 'Blue Book' could confer convenience and benefits on both patients and clinicians. Moreover, the patient combined primary biliary cirrhosis (PBC), which is a relatively rare condition compared to the underlying medical condition of viral cirrhosis. Due to atypical clinical symptoms and invasive biopsy of lymphoma, sometimes, diagnoses might be undesired, which eventually leads to a poor prognosis. With this case report, it reminds not just hematologists but also other specialists to pay attention to the updates and revisions of the classifications of lymphoma.
世界卫生组织淋巴造血系统肿瘤分类（WHO-HAEM5）第5版的特点是其分级分类系统和新的实体/类型。考虑到临床表现和预后的显著差异，液体超负荷相关大B细胞淋巴瘤（FOALBCL）已被纳入WHO-HAEM5，与原发性渗出性淋巴瘤的传统诊断不同。在本手稿中，我们报告了一名被诊断为FOALBCL的患者，这是WHO-HAEM5中引入的一个新实体。这是成功应用更新后的WHO-HAEM5的一个实例，表明《蓝皮书》可以为患者和临床医生带来便利和益处。此外，该患者合并原发性胆汁性肝硬化（PBC），与潜在的病毒性肝硬化疾病相比，这是一种相对罕见的情况。由于淋巴瘤的非典型临床症状和侵入性活检，有时诊断可能不理想，最终导致预后不良。通过本病例报告，它不仅提醒血液科医生，也提醒其他专科医生关注淋巴瘤分类的更新和修订。
