Longoria Jennifer N, Heitzer Andrew M, Hankins Jane S, Trpchevska Ana, Porter Jerlym S
Department of Psychology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Hematology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Br J Haematol. 2022 May;197(3):260-270. doi: 10.1111/bjh.18041. Epub 2022 Feb 4.
Sickle cell disease (SCD) is an inherited blood disorder that is associated with developmental delays and neurocognitive deficits. This review details key findings related to neurocognitive outcomes for children and adults with emphasis on the impact of neurological correlates and disease severity. Associations between neurocognition, demographic factors and social determinants of health are also reviewed. Emerging literature has reported on the neurocognitive impact of SCD in children and adolescents in Africa and Europe, including children from immigrant communities. Neurocognitive deficits are linked to poor functional outcomes, including transition from paediatric to adult care, medication adherence and unemployment. Integrating neuropsychology into multidisciplinary care for individuals with SCD can assist with identification and management of neurocognitive concerns, intervention development, individualized care plan development and continued multidisciplinary research.
镰状细胞病（SCD）是一种遗传性血液疾病，与发育迟缓及神经认知缺陷相关。本综述详细阐述了与儿童和成人神经认知结果相关的关键发现，重点关注神经学关联因素和疾病严重程度的影响。还对神经认知、人口统计学因素及健康的社会决定因素之间的关联进行了综述。新出现的文献报道了SCD对非洲和欧洲儿童及青少年的神经认知影响，包括来自移民社区的儿童。神经认知缺陷与不良功能结局相关，包括从儿科护理向成人护理的过渡、药物依从性及失业。将神经心理学纳入SCD患者的多学科护理中，有助于识别和管理神经认知问题、制定干预措施、制定个性化护理计划以及持续开展多学科研究。
