Lazarchick J, Stubbs T M, Romein L, Van Dorsten J P, Loadholt C B
Am J Obstet Gynecol. 1986 May;154(5):1050-2. doi: 10.1016/0002-9378(86)90748-9.
The plasma fibronectin concentration was abnormally elevated (greater than 400 micrograms/ml) in 16 of 17 normotensive gravid women who subsequently developed preeclampsia. Of this group, 13 had elevated levels detectable greater than or equal to 4 weeks before the onset of hypertension. Our results indicate that plasma fibronectin levels can be abnormally increased long before the onset of clinical symptoms and that abnormalities of this glycoprotein may be an early indication of this pathologic process.
17名血压正常的妊娠女性中，有16名随后发展为子痫前期，其血浆纤连蛋白浓度异常升高（大于400微克/毫升）。在这组患者中，13名患者在高血压发作前至少4周就检测到纤连蛋白水平升高。我们的研究结果表明，在临床症状出现前很长一段时间，血浆纤连蛋白水平就可能异常升高，并且这种糖蛋白异常可能是这一病理过程的早期迹象。
