Wang Z H, Li W J, Tong S X
Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1992;12(4):223-6. doi: 10.1007/BF02887854.
We determined maternal and neonatal umbilical artery serum concentrations of fibronectin (Fn) in 15 pregnant women with idiopathic IUGR (Intrauterine growth retardation) and 17 normal pregnant women at the time of delivery, by use of a rate nephelometric procedure. The results showed that the maternal serum levels of Fn in pregnant women with idiopathic IUGR were significantly higher than those in normal pregnant women at the time of delivery (P < 0.01), but umbilical artery serum concentrations in the two groups were not significantly different (P > 0.05), suggesting that the significant increase in maternal serum levels of Fn appeared to be related to uteroplacental vascular endothelial cell lesion, formation of microthrombi and deficiency of placental perfusion.
我们采用速率散射比浊法，测定了15例特发性宫内生长受限（IUGR）孕妇和17例正常孕妇分娩时母血及新生儿脐动脉血清中纤连蛋白（Fn）的浓度。结果显示，特发性IUGR孕妇分娩时母血Fn水平显著高于正常孕妇（P<0.01），但两组脐动脉血清浓度差异无统计学意义（P>0.05），提示母血Fn水平显著升高似乎与子宫胎盘血管内皮细胞损伤、微血栓形成及胎盘灌注不足有关。
