Department of Chemistry, Fergusson College, Pune, 411004, Maharashtra, India.
Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, 411007, Maharashtra, India.
Nanotheranostics. 2023 Mar 11;7(3):270-280. doi: 10.7150/ntno.81557. eCollection 2023.
A series of novel mixed transition metal-Magnesium tartarate complexes of general formulation [MMg(CHO) xHO] (where M = Mn, Fe, Co, Ni, Cu and Zn) is prepared with bidentate tartarate ligand. The synthesized complexes (C1 to C6) are characterized by various analytical techniques such as Elemental analysis, Thermo gravimetric analysis, FT-IR Spectroscopy, X-ray Diffraction, Magnetic susceptibility study etc. All complexes exhibit the composition MMgL where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) and L = bidentate tartarate ligand. Analytical data reveals all complexes possesses 1:1 (metal: ligand) ratio. FT-IR spectral study shows that bidentate tartarate ligand coordinate with metal ion in a bidentate manner through two oxygen atoms. Thermo gravimetric analysis of all complexes shows that degradation curves of complexes agrees with recommended formulae of the complexes. X-ray diffraction technique suggests that all complexes (C1 to C6) are polycrystalline in nature. All newly synthesized metal tartarate complexes and ligand were screened for their anticancer activity against human breast cancer (MDA-MB-231) cell line. The bioassays of all these complexes showed C3 (Co) and C5 (Cu) Mg-tartarate complexes contains maximum antiproliferative activity at 200 µg/ml concentration on MDA-MB-231 cells as compared to other complexes. MDA-MB-231 cells treated with C3 (Co) and C5 (Cu) Mg-tartarate complexes also showed inhibition in cell migration.
一系列新型混合过渡金属-酒石酸镁配合物，通式为[MMg(CHO) xHO]（其中 M = Mn、Fe、Co、Ni、Cu 和 Zn），以双齿酒石酸配体合成。合成的配合物（C1 至 C6）通过元素分析、热重分析、FT-IR 光谱、X 射线衍射、磁化率研究等各种分析技术进行表征。所有配合物均显示出 MMgL 的组成，其中 M = Mn(II)、Fe(II)、Co(II)、Ni(II)、Cu(II)和 Zn(II)，L = 双齿酒石酸配体。分析数据表明所有配合物都具有 1:1（金属：配体）的比例。FT-IR 光谱研究表明，双齿酒石酸配体通过两个氧原子以双齿方式与金属离子配位。所有配合物的热重分析表明，配合物的降解曲线与配合物的推荐式相符。X 射线衍射技术表明，所有配合物（C1 至 C6）均为多晶态。新合成的金属酒石酸盐配合物和配体均对人乳腺癌（MDA-MB-231）细胞系进行了抗癌活性筛选。所有这些配合物的生物测定结果表明，C3（Co）和 C5（Cu）Mg-酒石酸盐配合物在 200 µg/ml 浓度下对 MDA-MB-231 细胞的增殖抑制活性最高，与其他配合物相比。用 C3（Co）和 C5（Cu）Mg-酒石酸盐配合物处理的 MDA-MB-231 细胞也显示出细胞迁移抑制。
