Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.
Nanoscale. 2018 Oct 18;10(40):19082-19091. doi: 10.1039/c8nr05164j.
Specific targeting and phototriggered therapy in mouse model have recently emerged as the starting point of cancer theragnosis. Herein, we report a bioresponsive and degradable nanohybrid, a liposomal nanohybrid decorated with red emissive carbon dots, for localized tumor imaging and light-mediated tumor growth inhibition. Unsaturated carbon dots (C-dots) anchored to liposomes convert near-infrared (NIR) light into heat and also produce reactive oxygen species (ROS), demonstrating the capability of phototriggered cancer cell death and tumor regression. The photothermal and oxidative damage of breast tumor by the nonmetallic nanohybrid has also been demonstrated. Designed nanoparticles show excellent aqueous dispersibility, biocompatibility, light irradiated enhanced cellular uptake, release of reactive oxygen species, prolonged and specific tumor binding ability and good photothermal response (62 °C in 5 minutes). Safe and localized irradiation of 808 nm light demonstrates significant tumor growth inhibition and bioresponsive degradation of the fluorescent nanohybrid without affecting the surrounding healthy tissues.
最近，在小鼠模型中，针对特定靶点的光触发治疗已成为癌症治疗的起点。在此，我们报告了一种生物响应性和可降解的纳米杂化材料，它是一种带有红色发射碳点的脂质体纳米杂化材料，用于局部肿瘤成像和光介导的肿瘤生长抑制。锚定在脂质体上的不饱和碳点（C-dots）将近红外（NIR）光转化为热量，同时产生活性氧（ROS），证明了光触发癌细胞死亡和肿瘤消退的能力。非金属纳米杂化材料还展示了对乳腺癌的光热和氧化损伤。设计的纳米粒子具有优异的水分散性、生物相容性、光照射增强的细胞摄取、活性氧的释放、延长和特异性肿瘤结合能力以及良好的光热响应（5 分钟内达到 62°C）。808nm 光的安全和局部照射显著抑制肿瘤生长，并使荧光纳米杂化材料发生生物响应性降解，而不会影响周围的健康组织。
