Miconazole and ketoconazole as a satisfactory first-line treatment for keratomycosis.

In 20 patients (11 males and nine females, 3 to 65 years old) with fungal keratitis, Fusarium was identified in eight cases, Aspergillus in four, Drechslera in three, and Curvularia, Candida, and Nocardia in one each. In two cases the organism was not identified. Treatment with topical and subconjunctival miconazole along with ketoconazole resulted in healing in 13 cases. Modification of this regimen produced healing in three additional cases. Four cases progressed to blindness despite therapy.