真菌性角膜炎的当前思考：诊断与治疗
Current Thoughts in Fungal Keratitis: Diagnosis and Treatment.
作者信息
Ansari Zubair, Miller Darlene, Galor Anat
机构信息
Bascom Palmer Eye Institute, University of Miami, 900 NW 17 Street, Miami, FL 33136 USA ; Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL 33125 USA ; Marshall University Joan C. Edwards School of Medicine, 1600 Medical Center Dr. Huntington, WV 25701 USA.
出版信息
Curr Fungal Infect Rep. 2013 Sep 1;7(3):209-218. doi: 10.1007/s12281-013-0150-110.1007/s12281-013-0150-1.
Abstract
Fungal keratitis remains a challenging and often elusive diagnosis in geographic regions where it is endemic. Marred by delays in diagnosis, the sequelae of corneal fungal infections, though preventable, can be irreversible. Recent studies and advances in the arena have broadened the approach and treatment to mycotic keratitis. This review will discuss current diagnostic modalities of fungal keratitis and will particularly focus on treatment regimens. It will also explore future therapeutic models and critique the potential benefit of each.
摘要
在真菌性角膜炎流行的地区，它仍然是一个具有挑战性且常常难以确诊的疾病。由于诊断延误，角膜真菌感染的后遗症虽然可以预防，但可能是不可逆的。该领域最近的研究和进展拓宽了真菌性角膜炎的诊断方法和治疗手段。这篇综述将讨论真菌性角膜炎的当前诊断方式，并特别关注治疗方案。它还将探索未来的治疗模式，并对每种模式的潜在益处进行评估。
相似文献
1
Current Thoughts in Fungal Keratitis: Diagnosis and Treatment.真菌性角膜炎的当前思考：诊断与治疗
Curr Fungal Infect Rep. 2013 Sep 1;7(3):209-218. doi: 10.1007/s12281-013-0150-110.1007/s12281-013-0150-1.
2
Fungal Keratitis: Epidemiology, Rapid Detection, and Antifungal Susceptibilities of and Isolates from Corneal Scrapings.真菌性角膜炎：角膜刮片分离的 和 菌株的流行病学、快速检测和抗真菌药敏性。
Biomed Res Int. 2019 Jan 20;2019:6395840. doi: 10.1155/2019/6395840. eCollection 2019.
3
Evaluation of agent and host factors in progression of mycotic keratitis: A histologic and microbiologic study of 167 corneal buttons.真菌性角膜炎进展中病原体与宿主因素的评估：对167个角膜植片的组织学和微生物学研究
Ophthalmology. 2002 Aug;109(8):1538-46. doi: 10.1016/s0161-6420(02)01088-6.
4
Recent Perspectives in the Management of Fungal Keratitis.真菌性角膜炎治疗的最新观点
J Fungi (Basel). 2021 Oct 26;7(11):907. doi: 10.3390/jof7110907.
5
Multidrug-resistant Fusarium keratitis: diagnosis and treatment considerations.多重耐药性镰刀菌角膜炎：诊断与治疗考量
BMJ Case Rep. 2016 Aug 3;2016:bcr2016215401. doi: 10.1136/bcr-2016-215401.
6
Recent advances in diagnosis and management of Mycotic Keratitis.真菌性角膜炎诊断与治疗的最新进展
Indian J Ophthalmol. 2016 May;64(5):346-57. doi: 10.4103/0301-4738.185592.
7
Contact lens-related Fusarium infection: case series experience in New York City and review of fungal keratitis.隐形眼镜相关镰刀菌感染：纽约市的病例系列经验及真菌性角膜炎综述
Eye Contact Lens. 2007 Nov;33(6 Pt 1):322-8. doi: 10.1097/ICL.0b013e3180645d17.
8
Diagnosis and treatment outcome of mycotic keratitis at a tertiary eye care center in eastern India.在印度东部的一家三级眼科保健中心对真菌性角膜炎的诊断和治疗结果。
BMC Ophthalmol. 2011 Dec 22;11:39. doi: 10.1186/1471-2415-11-39.
9
Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis: A Secondary Analysis From the Mycotic Ulcer Treatment Trial II.伏立康唑口服辅助治疗镰刀菌角膜炎：真菌性溃疡治疗试验II的二次分析
JAMA Ophthalmol. 2017 Jun 1;135(6):520-525. doi: 10.1001/jamaophthalmol.2017.0616.
10
Epidemiology and Clinical Management of keratitis in the Netherlands, 2005-2016.2005 - 2016年荷兰角膜炎的流行病学与临床管理
Front Cell Infect Microbiol. 2020 Apr 3;10:133. doi: 10.3389/fcimb.2020.00133. eCollection 2020.
引用本文的文献
1
Nanomedicine in fungal keratitis: current applications and future prospects.纳米医学在真菌性角膜炎中的应用现状与未来展望
Front Microbiol. 2025 Jul 9;16:1618046. doi: 10.3389/fmicb.2025.1618046. eCollection 2025.
2
Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.真菌性角膜炎低温等离子体消融的最佳浸润深度阈值
J Ophthalmic Inflamm Infect. 2025 Jul 1;15(1):52. doi: 10.1186/s12348-025-00501-w.
3
First report of Stemphylium lycopersici keratitis, a complex corneal infection case.番茄匍柄霉角膜炎的首例报告，一例复杂的角膜感染病例。
J Ophthalmic Inflamm Infect. 2025 May 27;15(1):46. doi: 10.1186/s12348-025-00505-6.
4
Lasiodiplodia keratitis: A case series of 27 patients.莱氏 Diplodia 角膜炎：27 例病例系列
Indian J Ophthalmol. 2025 Jun 1;73(Suppl 3):S394-S398. doi: 10.4103/IJO.IJO_1677_24. Epub 2025 Apr 17.
5
An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis.罕见真菌引起的真菌性角膜炎的全球新威胁：一项系统评价和荟萃分析
Transl Vis Sci Technol. 2025 Apr 1;14(4):4. doi: 10.1167/tvst.14.4.4.
6
Comparative analysis of the therapeutic efficacy of low-temperature plasma ablation in treating fungal keratitis caused by various strains.低温等离子体消融术治疗不同菌株引起的真菌性角膜炎的疗效比较分析
Int Ophthalmol. 2025 Feb 10;45(1):68. doi: 10.1007/s10792-025-03440-6.
7
The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti- activity and in a treatment model of fungal keratitis.哺乳动物 Ire1 抑制剂 4µ8C 表现出广谱的抗病毒活性，并在真菌性角膜炎的治疗模型中显示出疗效。
Front Cell Infect Microbiol. 2024 Nov 12;14:1477463. doi: 10.3389/fcimb.2024.1477463. eCollection 2024.
8
The mammalian Ire1 inhibitor, 4μ8C, exhibits broad anti- activity and in a treatment model of fungal keratitis.哺乳动物Ire1抑制剂4μ8C在真菌性角膜炎治疗模型中具有广泛的抗活性。
bioRxiv. 2024 Aug 8:2024.08.08.607189. doi: 10.1101/2024.08.08.607189.
9
Overview of Mycotic Keratitis.真菌性角膜炎概述。
Cornea. 2024 Sep 1;43(9):1065-1071. doi: 10.1097/ICO.0000000000003559. Epub 2024 May 8.
10
Oriented cellulose hydrogel: Directed tissue regeneration for reducing corneal leukoplakia and managing fungal corneal ulcers.定向纤维素水凝胶：用于减少角膜白斑和治疗真菌性角膜溃疡的定向组织再生。
Bioact Mater. 2024 Jul 9;41:15-29. doi: 10.1016/j.bioactmat.2024.07.008. eCollection 2024 Nov.
本文引用的文献
1
Diagnosis of fungal keratitis: current options.真菌性角膜炎的诊断：当前的选择。
Expert Opin Med Diagn. 2012 Sep;6(5):449-55. doi: 10.1517/17530059.2012.679656. Epub 2012 Apr 16.
2
The role of penetrating keratoplasty in the era of selective lamellar keratoplasty.穿透性角膜移植术在选择性板层角膜移植术时代的作用。
Int Ophthalmol Clin. 2013 Spring;53(2):91-101. doi: 10.1097/IIO.0b013e31827823dd.
3
Mycotic keratitis: epidemiology, diagnosis and management.真菌性角膜炎：流行病学、诊断与治疗。
Clin Microbiol Infect. 2013 Mar;19(3):210-20. doi: 10.1111/1469-0691.12126. Epub 2013 Feb 9.
4
Comparative evaluation of topical versus intrastromal voriconazole as an adjunct to natamycin in recalcitrant fungal keratitis.局部与基质内伏立康唑作为难治性真菌性角膜炎辅助治疗与那他霉素的比较评价。
Ophthalmology. 2013 Apr;120(4):677-81. doi: 10.1016/j.ophtha.2012.09.023. Epub 2012 Dec 12.
5
Factors affecting treatment outcomes with voriconazole in cases with fungal keratitis.影响伏立康唑治疗真菌性角膜炎疗效的因素。
Cornea. 2013 Apr;32(4):445-9. doi: 10.1097/ICO.0b013e318254a41b.
6
Evaluation of molecular diagnosis in fungal keratitis. Ten years of experience.真菌性角膜炎的分子诊断评估。十年经验。
J Ophthalmic Inflamm Infect. 2011 Feb 23;1(1):15-22. doi: 10.1007/s12348-011-0019-9.
7
Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series.评价难治性真菌性角膜炎中基质内伏立康唑注射的疗效：病例系列。
Br J Ophthalmol. 2011 Dec;95(12):1735-7. doi: 10.1136/bjo.2010.192815. Epub 2011 Mar 31.
8
The effects of intrastromal voriconazole injection and topical voriconazole in the treatment of recalcitrant Fusarium keratitis.基质内注射伏立康唑联合局部滴注伏立康唑治疗顽固型镰刀菌角膜炎的效果。
Cornea. 2011 Aug;30(8):872-5. doi: 10.1097/ICO.0b013e3182100993.
9
Effects of time, temperature, and storage container on the growth of Fusarium species: implications for the worldwide Fusarium keratitis epidemic of 2004-2006.时间、温度和储存容器对镰刀菌属生长的影响：对2004 - 2006年全球镰刀菌性角膜炎流行的启示
Arch Ophthalmol. 2011 Feb;129(2):133-6. doi: 10.1001/archophthalmol.2010.338.
10
Clinical and microbiological characteristics of fungal keratitis in the United States, 2001-2007: a multicenter study.2001-2007 年美国真菌性角膜炎的临床和微生物学特征：一项多中心研究。
Ophthalmology. 2011 May;118(5):920-6. doi: 10.1016/j.ophtha.2010.09.011. Epub 2011 Feb 4.
Zotero 插件