2019年冠状病毒病信使核糖核酸疫苗接种后针对严重急性呼吸综合征冠状病毒2变异株的纵向中和及功能性抗体反应
Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination.
作者信息
Chen Xuemin, Ciric Caroline, Gibson Theda, Anderson Larry J, Anderson Evan J, Rostad Christina A
机构信息
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
出版信息
Open Forum Infect Dis. 2023 Mar 28;10(4):ofad167. doi: 10.1093/ofid/ofad167. eCollection 2023 Apr.
In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.
在美国这项针对健康成年人的纵向前瞻性队列研究中，我们发现2019冠状病毒病信使核糖核酸（mRNA）基础免疫系列和加强疫苗接种可诱导产生高滴度的广泛交叉反应性中和抗体及抗体依赖性细胞介导的细胞毒性抗体，这些抗体在6个月内逐渐减弱，尤其是针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体的抗体。这些数据支持进行后续加强疫苗接种的指征。
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