Starr Christopher R, Gorbatyuk Marina S
Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Cell Neurosci. 2023 Mar 30;17:1150220. doi: 10.3389/fncel.2023.1150220. eCollection 2023.
Posttranslational modifications (PTMs) are known to constitute a key step in protein biosynthesis and in the regulation of protein functions. Recent breakthroughs in protein purification strategies and current proteome technologies make it possible to identify the proteomics of healthy and diseased retinas. Despite these advantages, the research field identifying sets of posttranslationally modified proteins (PTMomes) related to diseased retinas is significantly lagging, despite knowledge of the major retina PTMome being critical to drug development. In this review, we highlight current updates regarding the PTMomes in three retinal degenerative diseases-namely, diabetic retinopathy (DR), glaucoma, and retinitis pigmentosa (RP). A literature search reveals the necessity to expedite investigations into essential PTMomes in the diseased retina and validate their physiological roles. This knowledge would accelerate the development of treatments for retinal degenerative disorders and the prevention of blindness in affected populations.
翻译后修饰（PTMs）是蛋白质生物合成和蛋白质功能调节中的关键步骤。蛋白质纯化策略和当前蛋白质组技术的最新突破使鉴定健康和患病视网膜的蛋白质组学成为可能。尽管有这些优势，但识别与患病视网膜相关的翻译后修饰蛋白质组（PTMomes）的研究领域仍明显滞后，尽管主要视网膜PTMome的知识对药物开发至关重要。在本综述中，我们重点介绍了三种视网膜退行性疾病——糖尿病性视网膜病变（DR）、青光眼和视网膜色素变性（RP）——中PTMomes的最新情况。文献检索表明，有必要加快对患病视网膜中必需PTMomes的研究，并验证它们的生理作用。这些知识将加速视网膜退行性疾病治疗方法的开发，并预防受影响人群失明。
