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创伤后应激障碍在经历唐山地震 35 年后的精神分裂症患者中的研究。

A study of post-traumatic stress disorder in schizophrenic patients 35 years after experiencing the Tangshan earthquake.

机构信息

Department of Clinical Psychology, Kailuan Mental Health Center Affiliated to North China University of Science and Technology, Tangshan, Hebei, China.

Department of Children and Adolescents, Second People's Hospital of Huizhou, Huizhou, China.

出版信息

Brain Behav. 2023 May;13(5):e2963. doi: 10.1002/brb3.2963. Epub 2023 Apr 17.

DOI:10.1002/brb3.2963
PMID:37067013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10175968/
Abstract

BACKGROUND

This study aimed to investigate the relationship between dissociative experiences, post-traumatic stress disorder (PTSD), and psychiatric symptoms exhibited by schizophrenic patients 35 years after the Tangshan earthquake.

METHODS

Seventy-one schizophrenic patients who had experienced the Tangshan earthquake were selected and evaluated by the Post-traumatic Dissociative Experience Questionnaire (PDEQ), thPTSD Checklist-Civilian Version (PCL-C), and the Positive and Negative Symptom Scale (PANSS).

RESULTS

The score of Group B (re-experiencing symptoms) in PCL-C was significantly positively correlated with age and significantly negatively correlated with the course of schizophrenia. Both gender and marriage were significantly positively correlated with the score of PCL-C Group D (irritability symptoms caused by hyperarousal). The PDEQ score was negatively correlated with thecourse of schizophrenia and positively correlated with the presence of sleep difficulties. Significant differences were found between the PCL-C scores of the positive and negative symptoms of the three core symptom groups; the positive rate of Group B was significantly higher than that of Group D, and the positive rate of Group C was significantly higher than that of Group D. The PCL-C total score was positively correlated with the negative symptom factor score of PANSS; Group C's symptoms were significantly negativelycorrelated with the positive factor score of PNASS; andGroup D's' symptoms were significantly negatively correlated with the PANSS total score and the positive factor score.

CONCLUSION

When consiering patients with schizophrenia post the Tangshan earthquake, age, gender, and marital status were all positively correlated with PTSD. The course of schizophrenia was negatively associated with PTSD and dissociative experiences. PTSD was positively correlated with the negative symptoms of schizophrenia and negatively correlated with the positive symptoms of schizophrenia. Thus, the conditions and symptoms of PTSD may interact with those of schizophrenia.

摘要

背景

本研究旨在探讨唐山地震 35 年后精神分裂症患者的分离体验、创伤后应激障碍(PTSD)和精神症状之间的关系。

方法

选取 71 例经历过唐山地震的精神分裂症患者,采用创伤后分离体验问卷(PDEQ)、创伤后应激障碍检查表-平民版(PCL-C)和阳性和阴性症状量表(PANSS)进行评估。

结果

PCL-C 组 B(再体验症状)评分与年龄呈显著正相关,与精神分裂症病程呈显著负相关。性别和婚姻状况与 PCL-C 组 D(高唤醒引起的易怒症状)评分呈显著正相关。PDEQ 评分与精神分裂症病程呈负相关,与睡眠困难呈正相关。三组核心症状的 PCL-C 评分存在显著差异;组 B 的阳性率明显高于组 D,组 C 的阳性率明显高于组 D。PCL-C 总分与 PANSS 阴性症状因子评分呈正相关;组 C 的症状与 PANSS 阳性因子评分呈显著负相关;组 D 的症状与 PANSS 总分和阳性因子评分呈显著负相关。

结论

在考虑唐山地震后精神分裂症患者时,年龄、性别和婚姻状况与 PTSD 呈正相关。精神分裂症病程与 PTSD 和分离体验呈负相关。PTSD 与精神分裂症的阴性症状呈正相关,与精神分裂症的阳性症状呈负相关。因此,PTSD 的情况和症状可能与精神分裂症的情况和症状相互作用。

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HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation.抑郁症和精神分裂症发病机制中的下丘脑-垂体-肾上腺轴:基于其参与作用的新治疗策略
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Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health.精神分裂症中的自主神经系统功能障碍:对认知和代谢健康的影响。
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PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.创伤后应激障碍相关的大脑功能、结构和生物化学的神经影像学异常。
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Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable.创伤后应激障碍中的神经内分泌系统功能障碍:概述及对性别作为生物学变量的考虑。
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