Laboratory of Vascular Nanopharmacology, Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Laboratory of Vascular Nanopharmacology, Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1524, ICB I, sala 319, 3° andar, Butantan, Sao Paulo 05508-900, Brazil.
Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666231162252. doi: 10.1177/17534666231162252.
Coronavirus-induced diseases have afflicted humanity for several decades. This scenario was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in Wuhan, China, in December 2019. Since then, COVID-19 has killed millions of people worldwide, probably the most devastating pandemic since HIV/AIDS. This review aimed to bring together important updated aspects related to coronavirus-induced diseases and the enhanced vascular permeability observed mainly in the lungs of affected people. The dysregulated vascular permeability in the lungs is of fundamental importance for coronaviruses-caused morbidity and mortality. Thus, as described in this review, it is a target of new and old drugs.
冠状病毒引起的疾病已经困扰了人类几十年。这种情况因 2019 年 12 月中国武汉出现的冠状病毒疾病 2019（命名为 COVID-19）而加剧。自那时以来，COVID-19 已在全球范围内导致数百万人死亡，这可能是自艾滋病以来最具破坏性的大流行。本次综述旨在汇集与冠状病毒引起的疾病以及在受影响人群的肺部中观察到的增强的血管通透性相关的重要最新方面。肺部的血管通透性失调对冠状病毒引起的发病率和死亡率至关重要。因此，正如本综述所述，它是新老药物的靶点。
