Huchon G, Choudat D, Papillon F, Chinet T, Dusser D, Chrétien J
Ann Med Interne (Paris). 1986;137(1):10-3.
As asthma is nearly always associated with non-specific bronchial hyperreactivity, this factor has been considered to be an essential requirement for the development of symptomatic asthma. Some factors appear to be inducers of bronchial hyperreactivity and others promotors of asthmatic symptoms. In clinical practice, it is very difficult to classify aetiological factors as inducers or promotors: there is evidence to support the fact that the same factors may cause both bronchial hyperreactivity and asthmatic symptoms; conversely, the evidence for hereditary non-specific bronchial hyperreactivity is hardly convincing. These observations suggest that non- specific bronchial hyperreactivity is more a marker of bronchial asthma than a true aetiological factor.
由于哮喘几乎总是与非特异性支气管高反应性相关，因此该因素被认为是症状性哮喘发生的必要条件。一些因素似乎是支气管高反应性的诱导因素，而另一些则是哮喘症状的促进因素。在临床实践中，很难将病因因素归类为诱导因素或促进因素：有证据支持这样的事实，即相同的因素可能导致支气管高反应性和哮喘症状；相反，遗传性非特异性支气管高反应性的证据几乎没有说服力。这些观察结果表明，非特异性支气管高反应性与其说是支气管哮喘的真正病因，不如说是支气管哮喘的一个标志。
