Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
The International Campus of Medicine, Iran University of Medical Sciences, Tehran, Iran.
BMC Psychiatry. 2023 Apr 17;23(1):262. doi: 10.1186/s12888-023-04696-x.
Today, gabapentinoids such as Gabapentin (GBP) and pregabalin (PGB) are widely used as painkillers. This may alter the function of the nervous system; hence their results may include a difference in memory and processes that end in memory formation. This study aims to conclude whether gabapentinoids can alter memory or not by reviewing and analyzing clinical and preclinical studies.
A comprehensive search was carried out in databases including PUBMED, EMBASE, SCOPUS, and Web of Science. In the included studies, memory was measured as an outcome variable in clinical or preclinical studies.
A total of 21 articles (4 clinical, 17 preclinical) were included in the meta-analysis by STATA Software. The results showed that memory changes under the influence of GBP. Both the administrated dosage and the time of administration are important in the final results and latency time of retention. GBP administration in healthy animals increased latency time, whereas if the administration of GBP took place exactly before training, the latency time increased slightly. Short-term administration of PGB in healthy volunteers is accompanied by transient side effects on the CNS. However, the number and homogeneity of the studies were not such that a meta-analysis could be performed on them.
Clinical and preclinical studies showed that PGB administration did not confirm its improving memory effect. GBP administration in healthy animals increased latency time and improved memory. Although it depended on the time of administration.
如今，加巴喷丁类药物（如加巴喷丁（GBP）和普瑞巴林（PGB））被广泛用作止痛药。这可能会改变神经系统的功能；因此，它们的结果可能包括记忆力和记忆形成过程的差异。本研究旨在通过回顾和分析临床前和临床研究来得出加巴喷丁类药物是否会改变记忆的结论。
在包括 PUBMED、EMBASE、SCOPUS 和 Web of Science 在内的数据库中进行了全面搜索。在纳入的研究中，记忆作为临床或临床前研究的结果变量进行了测量。
共有 21 篇文章（4 篇临床，17 篇临床前）通过 STATA 软件纳入荟萃分析。结果表明，GBP 会影响记忆变化。给药剂量和给药时间对最终结果和保留潜伏期都很重要。在健康动物中给予 GBP 会增加潜伏期，而如果在训练前正好给予 GBP，则潜伏期会略有增加。在健康志愿者中短期给予 PGB 会伴随短暂的中枢神经系统副作用。然而，研究的数量和同质性不足以对其进行荟萃分析。
临床和临床前研究表明，PGB 给药并不能证实其改善记忆的效果。在健康动物中给予 GBP 会增加潜伏期并改善记忆。尽管这取决于给药时间。
