Department of Biotechnology, Translational Research Laboratory, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India.
Department of Forensic Science, i/c Salakati Police Station, Kathalguri No.2, Kokrajhar, Assam, 783370, India.
Curr Pharm Biotechnol. 2023;24(15):1847-1858. doi: 10.2174/1389201024666230413084603.
Lipids have received less attention than nucleic acids and proteins, which play a major role in building up the cell. They are a complex group of biomolecules varying in structure and function whose complexity can only be revealed by refining the present analytical tools. Lipogenesis is critical for tumor growth as it has been observed that FA (Fatty Acid) synthesis increases in many cancers. In this review, we have detailed the causes and concerns for considering lipids as a trademark for cancer, including other events such as mutations, epigenetic changes, chromosomal rearrangements, and hormonal stimulations. The process of biomarker development can be heightened from the critical changes observed in lipid profiling that occur in the reprogramming of lipid metabolism. The cancer alterations that occur during lipid metabolism and the expression of various genes during this process have been discussed in detail. The routes through which cancer cells source lipids for their nourishment and energy need and how FA synthesis contributes to this are discussed. The various pathways involved in the metabolism of lipid, which has the potential to be therapeutic targets, are highlighted. Also, the various driving factors critical for lipid metabolism alterations and the major role played by lipids in cancer and ways of targeting it are critically analyzed.
脂质受到的关注不如在构建细胞中起主要作用的核酸和蛋白质多。它们是结构和功能各异的复杂生物分子群体，只有通过改进现有分析工具才能揭示其复杂性。脂肪生成对于肿瘤生长至关重要，因为已经观察到在许多癌症中脂肪酸合成增加。在这篇综述中，我们详细说明了将脂质作为癌症标志的原因和关注点，包括突变、表观遗传变化、染色体重排和激素刺激等其他事件。通过观察脂质代谢重编程过程中脂质谱分析中发生的关键变化，可以提高生物标志物的开发过程。详细讨论了脂质代谢过程中发生的癌症改变以及在此过程中各种基因的表达。讨论了癌细胞获取营养和能量所需的脂质来源途径以及脂肪酸合成对此的贡献。突出了具有治疗靶点潜力的脂质代谢的各种途径。还批判性地分析了脂质代谢改变的关键驱动因素以及脂质在癌症中的主要作用及其靶向方法。
