Department of Periodontology, School of Dentistry, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil.
Postgraduate Program in Dentistry, School of Dentistry, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil.
Eur J Oral Sci. 2023 Jun;131(3):e12931. doi: 10.1111/eos.12931. Epub 2023 Apr 17.
The aim of the present study was to perform a systematic review of the literature regarding the effect of different mouthwashes on gingival healing after oral surgery in adults. Searches were conducted in seven databases (PubMed/MEDLINE, Cochrane Library, Clinical Trials Registry, Embase, LILACS, Web of Science, and Google Scholar) for relevant randomized controlled trials (RCTs) published up to April 2022. The selection of studies, data extraction, and risk of bias appraisal were performed independently by two reviewers, and a third researcher was consulted to resolve disagreements. Data syntheses were presented narratively for the different criteria of gingival wound healing. Among 4502 articles retrieved from the databases, 13 studies met the eligibility criteria and were included in the present review. Chlorhexidine was the most frequent mouthwash studied (eight studies) and was used in different concentrations and combinations. Cetylpyridinium chloride, H Ocean Sea Salt, Commiphora molmol 0.5%, chlorhexidine 0.12%, and essential oils reported better healing than a negative control. However, the uncertain risk of bias in most RCTs included in this review precludes definitive conclusions. Well-designed RCTs are therefore still needed in this area.
本研究旨在对成人口腔手术后不同漱口水对牙龈愈合影响的文献进行系统综述。研究人员在七个数据库（PubMed/MEDLINE、Cochrane 图书馆、临床试验注册处、Embase、LILACS、Web of Science 和 Google Scholar）中进行了检索，以查找截至 2022 年 4 月发表的相关随机对照试验（RCT）。两名评审员独立进行了研究选择、数据提取和偏倚风险评估，如有分歧则由第三位研究人员进行咨询。根据不同的牙龈伤口愈合标准，以叙述的方式呈现数据综合结果。从数据库中检索到 4502 篇文章，其中 13 项研究符合纳入标准，并纳入本综述。氯己定是研究最多的漱口水（8 项研究），并以不同浓度和组合使用。氯化十六烷基吡啶、H Ocean Sea Salt、没药 0.5%、氯己定 0.12%和精油的愈合效果优于阴性对照。然而，本综述中纳入的大多数 RCT 存在不确定的偏倚风险，因此无法得出明确的结论。因此，该领域仍需要设计良好的 RCT 研究。
