Almasyan Rika, Jafari Parvaneh, Farjanikish Ghasem, Noorbazargan Hassan
Department of Microbiology, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran.
Iran J Microbiol. 2023 Feb;15(1):102-110. doi: 10.18502/ijm.v15i1.11924.
Peptic ulcer disease is a multifactorial disease that affects up to 10% of people. The use of natural product remedies has received much attention for its treatment. In this research, the healing effect of metabiotic extracted from was investigated.
45 male wistar rats were divided into 3 groups (Ctrl-, drug, and metabiotic), and stomach ulcers were induced by ethanol administration and treated by drug and metabiotic. The healing process was investigated on different days by histological analysis and qRT-PCR.
The metabiotic increased IL-8 and PDGF expression and stimulated the recruitment of polymorphonuclear cells to the wound site. It caused a faster onset of the inflammation phase followed by the proliferation phase. The metabiotic increased the expression of SOD and GPx genes and the antioxidant capacity of the wound. The increase in EGF expression led to faster re-epithelization, which was evident in the wound closure process.
Metabiotic extracted from is a promising candidate for the treatment of PUD. It causes a faster onset of the inflammation phase. Improving the antioxidant status of the wound, causes a faster resolution of inflammation, which leads to the acceleration of the wound-healing process.
消化性溃疡病是一种多因素疾病，影响着多达10%的人群。天然产物疗法在其治疗方面备受关注。在本研究中，对从[未提及具体来源]提取的后生生物的愈合效果进行了研究。
将45只雄性Wistar大鼠分为3组（对照组、药物组和后生生物组），通过给予乙醇诱导胃溃疡，并分别用药物和后生生物进行治疗。通过组织学分析和qRT-PCR在不同天数对愈合过程进行研究。
后生生物增加了IL-8和PDGF的表达，并刺激多形核细胞向伤口部位募集。它使炎症期更快开始，随后进入增殖期。后生生物增加了SOD和GPx基因的表达以及伤口的抗氧化能力。EGF表达的增加导致更快的重新上皮化，这在伤口闭合过程中很明显。
从[未提及具体来源]提取的后生生物是治疗消化性溃疡病的一个有前景的候选物。它使炎症期更快开始。改善伤口的抗氧化状态，使炎症更快消退，从而加速伤口愈合过程。
