Abdulaziz Alsufyani Amal
College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
Saudi J Biol Sci. 2023 May;30(5):103649. doi: 10.1016/j.sjbs.2023.103649. Epub 2023 Apr 7.
The aim of this research is to analyze the potential impact of the COVID-19 infection on the serum biochemical concentration of children 6 months after recovery from the infection. The study included 72 children with a median age of 11 years. The case group consisted of 37 children who had contracted COVID-19 6 months prior to the analysis. They reported no other pre- or post-covid chronic or systemic diseases. The control group consisted of 35 children who had no prior record of COVID-19 infection. The analysis showed a substantial variation ( = 0.026) in the mean urea values (mmol/L) between the case group (4.513 ± 0.839) and the control group (5.425 ± 1.173). However, both groups' urea levels were within the normal range of their age group. No statistical differences were found analyzing the variations between the two groups in the levels of LDH, AST, ALT, BiliT, GGT, AlbBCG2, CRP, CK, AlKP, UA, Phos, Crea2, Gluc, Ca, Na, K, Cl, TP, TC, TG, and HDL ( > 0.05). The DMFT score was substantially greater ( < 0.002) in the infected team (5.38 ± 2.841) in comparison to the non-infected group (2.6 ± 2.257). The study indicates that COVID-19 infection does not leave biochemical alterations among children who did not have pre-existing conditions. The biochemical analysis suggests that children recover better than adults from COVID-19. Furthermore, it calls for investigating non-lethal COVID-19 infection as a tool to discover underlying conditions. The DMFT score shows a correlation between COVID-19 infection and caries. However, the nature of the correlation is yet to be investigated.
本研究的目的是分析新冠病毒感染康复6个月后对儿童血清生化浓度的潜在影响。该研究纳入了72名儿童，中位年龄为11岁。病例组由37名在分析前6个月感染新冠病毒的儿童组成。他们报告无其他新冠病毒感染前或感染后的慢性或全身性疾病。对照组由35名无新冠病毒感染既往史的儿童组成。分析显示，病例组（4.513±0.839）和对照组（5.425±1.173）的平均尿素值（mmol/L）存在显著差异（P = 0.026）。然而，两组的尿素水平均在其年龄组的正常范围内。分析两组在乳酸脱氢酶、谷草转氨酶、谷丙转氨酶、总胆红素、γ-谷氨酰转肽酶、白蛋白、C反应蛋白、肌酸激酶、碱性磷酸酶、尿酸、磷、肌酐、葡萄糖、钙、钠、钾、氯、总蛋白、总胆固醇、甘油三酯和高密度脂蛋白水平上的差异，未发现统计学差异（P>0.05）。感染组（5.38±2.841）的龋失补牙面数（DMFT）评分显著高于未感染组（2.6±2.257）（P<0.002）。该研究表明，新冠病毒感染在无基础疾病的儿童中不会留下生化改变。生化分析表明，儿童从新冠病毒感染中恢复得比成人更好。此外，该研究呼吁将非致死性新冠病毒感染作为发现潜在疾病的一种手段进行调查。DMFT评分显示新冠病毒感染与龋齿之间存在相关性。然而，这种相关性的本质尚待研究。
