van Leeuwen T G, Borst C
Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.
Semin Interv Cardiol. 1996 Jun;1(2):121-8.
Pulsed xenon chloride excimer and holmium laser-tissue interaction is primarily based on tissue water vaporization. Consequently, each ablative laser pulse produces a rapidly expanding and imploding vapour bubble in blood or the target tissue. In experimental studies, explosive water vaporization is the major mechanical cause of observed tissue dissections. By reduction of the induced bubble volume, a reduction in experimentally and clinically observed dissections after coronary excimer laser angioplasty is to be expected. This reduction of mechanical damage, however, in combination with efficient and substantial plaque debulking is the major challenge in the development of laser angioplasty.
脉冲氯化氙准分子激光和钬激光与组织的相互作用主要基于组织水汽化。因此，每个消融激光脉冲都会在血液或目标组织中产生一个迅速膨胀然后内爆的蒸汽泡。在实验研究中，爆炸性水汽化是观察到的组织切割的主要机械原因。通过减小诱导气泡的体积，预计在冠状动脉准分子激光血管成形术后，实验和临床观察到的切割现象会减少。然而，这种机械损伤的减少，再加上高效且显著的斑块减容，是激光血管成形术发展中的主要挑战。
