Lee G, Lee M H, Ikeda R M, Chan M C, Reis R L, Rink J L, Peterson L, Hanna E S, Mason D T
Cardiol Clin. 1984 Nov;2(4):621-31.
Laser energy delivered through optical fibers can produce potent controlled thermal dissolution of human coronary obstructive disease, thus widening the stenotic vascular lumen. The ease of vaporization and penetration depends not only on the physical properties of the laser beam but also on the physical characteristics of the atherosclerotic plaque. Lipid-laden plaques are more easily vaporized compared with plaques that are heavily calcified. In atherosclerotic animal models studied in vivo, laser radiation produced a charred lining around the evacuated area and rapid regeneration of a new endothelial lining. After several weeks, the laser-induced crater was still evident, and thrombogenesis was not a significant complication. Focal aneurysmal dilatation may develop when there is thermal injury of the medial layer, and acute perforation can occur if severe laser burn is extended beyond the adventitial layer. Further technical advances and achievements are needed before laser recanalization becomes a clinical reality.
通过光纤传输的激光能量能够对人类冠状动脉阻塞性疾病产生有效的可控热消融作用，从而拓宽狭窄的血管管腔。汽化和穿透的难易程度不仅取决于激光束的物理特性，还取决于动脉粥样硬化斑块的物理特征。与严重钙化的斑块相比，富含脂质的斑块更容易汽化。在体内研究的动脉粥样硬化动物模型中，激光辐射在排空区域周围产生烧焦的内膜，并使新的内皮内膜快速再生。几周后，激光诱导的弹坑仍然明显，血栓形成并非严重并发症。当中层受到热损伤时，可能会发生局灶性动脉瘤样扩张，如果严重的激光灼伤扩展到外膜层之外，可能会发生急性穿孔。在激光再通成为临床现实之前，还需要进一步的技术进步和成果。
