Cao Kai, Hao Jie, Wang Ning-Li
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Eur J Ophthalmol. 2023 Nov;33(6):2146-2153. doi: 10.1177/11206721231169613. Epub 2023 Apr 17.
To explore whether baseline visual impairment (VI) increases the risk of cognitive function impairment (CFI).
We conducted a population-based cohort study, with a six-year follow-up period. The exposure factor of interest in this study was VI. The Mini-Mental State Examination (MMSE) was used to assess participants' cognitive function. The Logistic regression model was used to investigate whether baseline VI had an effect on CFI. Confounding factors were adjusted in the regression model. The odds ratio (OR) and 95% confidence interval (CI) were used to quantify the effect of VI on CFI.
A total of 3297 participants were included in the present study. The mean age of included participants was 58.5 ± 7.2 years. Male accounted for 1480 (44.9%) of all participants. At baseline, 127 (3.9%) of the participants had VI. The MMSE score of participants who had VI at baseline decreased by 1.7 ± 3.3 points on average during the six-year follow-up, and that of participants who had no VI at baseline decreased by 1.1 ± 3.3 points on average. The difference was significant (t = 2.03, = 0.040). Results of the multivariable Logistic regression model showed that VI was a risk factor for CFI, with an OR of 1.052 (95%CI: 1.014 to 1.092, = 0.017).
Averagely, participants with VI experienced a decline in cognitive function 0.1 points faster per year than participants without VI, as measured by MMSE score. VI is an independent risk factor for CFI.
探讨基线视力损害（VI）是否会增加认知功能损害（CFI）的风险。
我们进行了一项基于人群的队列研究，随访期为六年。本研究感兴趣的暴露因素是VI。采用简易精神状态检查表（MMSE）评估参与者的认知功能。使用逻辑回归模型研究基线VI是否对CFI有影响。在回归模型中对混杂因素进行了调整。比值比（OR）和95%置信区间（CI）用于量化VI对CFI的影响。
本研究共纳入3297名参与者。纳入参与者的平均年龄为58.5±7.2岁。男性占所有参与者的1480名（44.9%）。基线时，127名（3.9%）参与者存在VI。基线时存在VI的参与者在六年随访期间MMSE评分平均下降1.7±3.3分，而基线时无VI的参与者MMSE评分平均下降1.1±3.3分。差异具有统计学意义（t = 2.03，P = 0.040）。多变量逻辑回归模型结果显示，VI是CFI的一个危险因素，OR为1.052（95%CI：1.014至1.092，P = 0.017）。
平均而言，以MMSE评分衡量，有VI的参与者认知功能每年下降速度比无VI的参与者快0.1分。VI是CFI的独立危险因素。
