Zhang Yiqiu, Ye Rongan, Dong Jiying, Bai Yubing, He Yu, Ni Wei, Yao Min
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University of Medicine, Shanghai, China.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
J Dermatolog Treat. 2023 Dec;34(1):2202287. doi: 10.1080/09546634.2023.2202287. Epub 2023 Apr 18.
Hypertrophic scarring is a complex process, and numerous methods have been introduced to treat scars. This study aims to evaluate the effect of combined CO fractional laser and narrowband intense pulsed light (IPL) compared to IPL alone in the treatment of hypertrophic scars.
This was a prospective, randomized controlled study enrolled 138 patients with hypertrophic scars. The participants were randomly divided into two groups: CO-IPL and IPL group, and received three sessions at 10-14-week intervals for 3-month follow-up. Two independent plastic surgeons evaluated the treatments using the Patient and Observer Scar Assessment Scales (POSAS). Overall satisfaction was evaluated using the Patient Satisfaction Scale (PSS).
101 subjects completed the study. Compared to single IPL, the combination CO-IPL group showed a significant improvement in itching, color, stiffness, thickness, and irregularity, except for pain, and an enhancement in vascularization, pigmentation, thickness, relief, and pliability of the scar, assessed by POSAS ( < .01). 100% patients in the combination group were satisfied compared to 84% in IPL alone.
The combination of CO fractional laser and narrowband IPL efficiently improved the appearance and profile of hypertrophic scars, offering a comprehensive and reliable approach for scar therapy.
肥厚性瘢痕形成是一个复杂的过程，目前已引入多种方法来治疗瘢痕。本研究旨在评估剥脱性二氧化碳点阵激光联合窄谱强脉冲光（IPL）与单纯IPL治疗肥厚性瘢痕的效果。
这是一项前瞻性随机对照研究，纳入了138例肥厚性瘢痕患者。参与者被随机分为两组：CO-IPL组和IPL组，每隔10 - 14周接受3次治疗，并进行3个月的随访。两名独立的整形外科医生使用患者和观察者瘢痕评估量表（POSAS）对治疗效果进行评估。使用患者满意度量表（PSS）评估总体满意度。
101名受试者完成了研究。与单纯IPL相比，CO-IPL联合治疗组在瘙痒、颜色、硬度、厚度和不规则度方面有显著改善（疼痛除外），通过POSAS评估，瘢痕的血管化、色素沉着、厚度、缓解程度和柔韧性也有所增强（P < 0.01）。联合治疗组100%的患者表示满意，而单纯IPL组为84%。
剥脱性二氧化碳点阵激光与窄谱IPL联合使用能有效改善肥厚性瘢痕的外观和形态，为瘢痕治疗提供了一种全面且可靠的方法。
