《马凡综合征韩国患者的眼部受累与治疗模式：一项基于人群的研究》。

Ocular Involvement and Treatment Pattern in Korean Patients with Marfan Syndrome: A Population-Based Study.

机构信息

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.

出版信息

Ophthalmic Epidemiol. 2024 Apr;31(2):112-118. doi: 10.1080/09286586.2023.2204153. Epub 2023 Apr 18.

DOI:10.1080/09286586.2023.2204153

PMID:37070930

Abstract

PURPOSE

This study aimed to investigate the incidence and prevalence of, and treatment patterns for ocular complications in Korean patients with Marfan syndrome.

METHODS

Incidence and prevalence of Marfan syndrome was calculated from 2010 to 2018, based on data from the Korean National Health Insurance Service (KNHIS). Diagnosis codes (for cataract, ectopia lentis, retinal detachment, etc.) and surgery reimbursement codes (lensectomy, phacoemulsification, buckling, vitrectomy, etc.) in the patients with Marfan syndrome were retrieved by complete enumeration of the data.

RESULTS

The annual prevalence of Marfan syndrome adjusted by age and sex was gradually increased from 2.44 per 100,000 in 2010 to 4.36 per 100,000 in 2018. The age group of 10-19 years showed the highest prevalence. The prevalence of ectopia lentis was 21.7%, of whom 43.0% underwent surgeries. Surgery for RD was performed in 253 (14.1%) of 2044 patients during the study period.

CONCLUSION

Although the most prevalent ophthalmologic manifestation was ectopia lentis, total prevalence rate of RD was more than 10% in the study period; thus, regular fundus examination is recommended for the patients with Marfan syndrome.

摘要

目的

本研究旨在调查韩国马凡综合征患者眼部并发症的发生率、患病率和治疗模式。

方法

根据韩国国民健康保险服务（KNHIS）的数据，计算了 2010 年至 2018 年马凡综合征的发病率和患病率。通过对数据进行完全列举，检索到马凡综合征患者的诊断代码（如白内障、晶状体异位、视网膜脱离等）和手术报销代码（晶状体切除术、超声乳化术、巩膜扣带术、玻璃体切除术等）。

结果

经年龄和性别调整的马凡综合征年患病率从 2010 年的每 10 万人 2.44 例逐渐增加到 2018 年的每 10 万人 4.36 例。10-19 岁年龄组的患病率最高。晶状体异位的患病率为 21.7%，其中 43.0%的患者接受了手术。在研究期间，2044 名患者中有 253 名（14.1%）接受了 RD 手术。