Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Clin Oral Investig. 2023 Aug;27(8):4083-4106. doi: 10.1007/s00784-023-05021-2. Epub 2023 Apr 18.
Patients with hematological malignancies have dynamic changes in oral microbial communities before and after treatment. This narrative review describes the changes in oral microbial composition and diversity, and discusses an oral microbe-oriented strategy for oral disease management.
A literature search was performed in PubMed/Medline, Web of Science, and Embase for articles published between 1980 and 2022. Any articles on the changes in oral microbial communities in patients with hematological malignancies and their effects on disease progression and prognosis were included.
Oral sample detection and oral microbial sequencing analysis of patients with hematological malignancies showed a correlation between changes in oral microbial composition and diversity and disease progression and prognosis. The possible pathogenic mechanism of oral microbial disorders is the impairment of mucosal barrier function and microbial translocation. Probiotic strategies, antibiotic strategies, and professional oral care strategies targeting the oral microbiota can effectively reduce the risk of oral complications and the grade of severity in patients with hematological malignancies.
This review provides dentists and hematologists with a comprehensive understanding of the host-microbe associated with hematologic malignancies and oral disease management advice.
血液系统恶性肿瘤患者在治疗前后口腔微生物群落会发生动态变化。本综述描述了口腔微生物组成和多样性的变化，并讨论了一种基于口腔微生物的口腔疾病管理策略。
在 PubMed/Medline、Web of Science 和 Embase 中检索了 1980 年至 2022 年期间发表的文献。纳入了关于血液系统恶性肿瘤患者口腔微生物群落变化及其对疾病进展和预后影响的所有文章。
对血液系统恶性肿瘤患者的口腔样本进行检测和口腔微生物测序分析，结果显示口腔微生物组成和多样性的变化与疾病进展和预后相关。口腔微生物失调的可能致病机制是黏膜屏障功能受损和微生物易位。针对口腔微生物的益生菌策略、抗生素策略和专业口腔护理策略可以有效降低血液系统恶性肿瘤患者口腔并发症的风险和严重程度。
本综述为牙医和血液科医生提供了对血液系统恶性肿瘤相关宿主-微生物的全面了解，并提供了口腔疾病管理建议。
