耐青霉素肺炎球菌的携带情况。
Carriage of penicillin resistant pneumococci.
作者信息
Klugman K P, Koornhof H J, Wasas A, Storey K, Gilbertson I
出版信息
Arch Dis Child. 1986 Apr;61(4):377-81. doi: 10.1136/adc.61.4.377.
A survey of 303 urban and 156 rural children showed nasopharyngeal carriage of relatively resistant Streptococcus pneumoniae organisms in 14.2% and 19.2% of children, respectively. These organisms have minimum inhibitory concentrations for penicillin in the range of 0.12-1 microgram/ml. An analysis of 40 relatively resistant S. pneumoniae strains showed resistance to co-trimoxazole in 47.5%, trimethoprim in 42.5%, fusidic acid in 20%, tetracycline in 2.5%, and rifampicin in 5%. All the strains were susceptible to chloramphenicol and vancomycin, while the minimum inhibitory concentrations of third generation cephalosporins and imipenem were comparable with or lower than those of penicillin. Eighty three per cent of the strains tested belonged to serogroups 6 and 19. These findings are discussed in relation to the poor clinical response to treatment with penicillin for relatively resistant S. pneumoniae meningitis, and the minimum inhibitory concentrations of alternate agents under review for treatment of systemic pneumococcal disease are presented.
一项针对303名城市儿童和156名农村儿童的调查显示，相对耐药的肺炎链球菌在城市儿童和农村儿童中的鼻咽部携带率分别为14.2%和19.2%。这些菌株对青霉素的最低抑菌浓度在0.12 - 1微克/毫升范围内。对40株相对耐药的肺炎链球菌菌株进行分析发现，它们对复方新诺明的耐药率为47.5%，对甲氧苄啶为42.5%，对夫西地酸为20%，对四环素为2.5%，对利福平为5%。所有菌株对氯霉素和万古霉素敏感，而第三代头孢菌素和亚胺培南的最低抑菌浓度与青霉素相当或更低。83%的受试菌株属于血清群6和19。结合相对耐药的肺炎链球菌脑膜炎用青霉素治疗临床反应不佳的情况对这些发现进行了讨论，并列出了正在审查的用于治疗全身性肺炎球菌疾病的替代药物的最低抑菌浓度。
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