Department of Internal Medicine, Renci Hospital, Siyang, Jiangsu, 223700, China.
Xiamen Road Branch Hospital, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian, 223002, China.
Curr Pharm Des. 2023;29(12):966-979. doi: 10.2174/1381612829666230417100144.
Patients with left carotid artery atherosclerotic stenosis have an increased ischemic stroke risk. Left carotid stenosis, the most common cause of the transient ischemic attack, is related to a higher risk of acute stroke. Left carotid artery stenosis is also associated with cerebral artery infarction. The significant coronary stenosis promotes ST-segment elevation myocardial infarctions. The severe coronary stenosis plays an important role in development and progression of myocardial infarction. However, the dynamic changes of circulating oxidative stress and inflammatory markers in the carotid stenosis combined with coronary artery stenosis are not clear, and it also remains unknown whether mark of oxidative stress and inflammation are potential therapeutic targets for carotid stenosis combined with coronary artery stenosis.
This study aims to explore the effects of oxidative stress combined with an inflammatory response on left carotid artery stenosis with coronary artery disease in patients.
We, therefore, tested the hypothesis that levels of markers of oxidative stress and inflammation are associated with coexistent severe carotid and coronary artery stenosis in patients. We measured the circulating levels of malondialdehyde (MDA), oxidized low-density lipoprotein (OX-LDL), homocysteine (Hcy), F2- isoprostanes (F2-IsoPs), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), prostaglandin E2 (PG-E2) and interferon-gamma (IFN-γ) in patients with combined carotid and coronary artery severe stenosis. We also assessed the relationships among oxidative stress, inflammation, and severe stenosis of the carotid with a coronary artery in patients.
Levels of MDA, OX-LDL, Hcy, F2-IsoPs, TNF-α, hs-CRP, PG-E2, and IFN-γ were remarkably increased (P < 0.001) in patients with combined carotid and coronary artery severe stenosis. High levels of oxidative stress and inflammation may be related to severe stenosis of the carotid with coronary arteries in patients.
Our observations indicated that measurements of oxidative stress and inflammatory markers may be valuable for the assessment of the degree of carotid with coronary artery stenosis. The biomarkers of oxidative stress and inflammatory response may become therapeutic targets for carotid artery stenosis with coronary artery stenosis in patients.
患有左侧颈动脉粥样硬化性狭窄的患者发生缺血性脑卒中的风险增加。左侧颈动脉狭窄是短暂性脑缺血发作最常见的原因，与急性脑卒中风险增加相关。左侧颈动脉狭窄也与脑动脉梗死有关。显著的冠状动脉狭窄促进 ST 段抬高型心肌梗死。严重的冠状动脉狭窄在心肌梗死的发展和进展中起着重要作用。然而，颈动脉狭窄合并冠状动脉狭窄患者循环氧化应激和炎症标志物的动态变化尚不清楚，氧化应激和炎症标志物是否是颈动脉狭窄合并冠状动脉狭窄的潜在治疗靶点也尚不清楚。
本研究旨在探讨氧化应激和炎症反应对伴有冠状动脉疾病的左侧颈动脉狭窄患者的影响。
因此，我们检验了这样一个假设，即氧化应激和炎症标志物的水平与伴有严重颈动脉和冠状动脉狭窄的患者有关。我们测量了伴有严重颈动脉和冠状动脉狭窄的患者循环中的丙二醛（MDA）、氧化型低密度脂蛋白（OX-LDL）、同型半胱氨酸（Hcy）、F2-异前列烷（F2-IsoPs）、肿瘤坏死因子-α（TNF-α）、高敏 C 反应蛋白（hs-CRP）、前列腺素 E2（PG-E2）和干扰素-γ（IFN-γ）的水平。我们还评估了氧化应激、炎症与伴有严重颈动脉和冠状动脉狭窄的患者之间的关系。
伴有严重颈动脉和冠状动脉狭窄的患者 MDA、OX-LDL、Hcy、F2-IsoPs、TNF-α、hs-CRP、PG-E2 和 IFN-γ 水平显著升高（P<0.001）。高水平的氧化应激和炎症可能与伴有严重颈动脉和冠状动脉狭窄的患者有关。
我们的观察表明，氧化应激和炎症标志物的测量可能对评估颈动脉和冠状动脉狭窄的程度有价值。氧化应激和炎症反应的生物标志物可能成为伴有冠状动脉狭窄的颈动脉狭窄患者的治疗靶点。
