Pearlman N W, Stiegmann G V, Ahnen D J, Schultz A L, Fink L M
Arch Surg. 1986 Jun;121(6):661-4. doi: 10.1001/archsurg.1986.01400060055006.
Acid and gastrin production after pyloric-preserving pancreaticoduodenectomy was evaluated in six patients. Five patients had low-normal basal and stimulated acid output; the sixth patient was achlorhydric. Fasting gastrin levels were less than 90 to 105 pg/mL (normal range) in five patients, three of whom had stimulated gastrin levels that remained below this range. Two patients had stimulated gastrin levels of 510 pg/mL and 205 pg/mL, respectively, within 15 minutes of eating; however, both levels returned to normal by 120 minutes' time. The sixth patient had mildly elevated fasting (105 pg/mL) and stimulated gastrin levels (160 to 200 pg/mL) throughout the test period. The results suggest that pyloric-preserving pancreaticoduodenectomy does not lead to either gastric hyperacidity or persistent hypergastrinemia.
对6例保留幽门的胰十二指肠切除术后患者的胃酸和胃泌素分泌情况进行了评估。5例患者基础胃酸分泌量和刺激胃酸分泌量处于低正常水平；第6例患者无胃酸分泌。5例患者的空腹胃泌素水平低于90至105 pg/mL（正常范围），其中3例患者的刺激胃泌素水平仍低于此范围。2例患者在进食后15分钟内刺激胃泌素水平分别为510 pg/mL和205 pg/mL；然而，到120分钟时，这两个水平均恢复正常。在整个测试期间，第6例患者的空腹胃泌素水平（105 pg/mL）和刺激胃泌素水平（160至200 pg/mL）轻度升高。结果表明，保留幽门的胰十二指肠切除术不会导致胃酸过多或持续性高胃泌素血症。
