Serret-Montoya Juana, Zurita-Cruz Jessie Nallely, Villasís-Keever Miguel Ángel, López-Beltrán Ana Laura, Espíritu-Díaz Mireya Elizabeth, Delgadillo-Ruano Martha Alicia, Gómez-Alba Mariana, Mendoza-Rojas Ofelia
Servicio de Medicina del Adolescente. Hospital Infantil de México Federico Gómez. Secretaría de Salud.
Facultad de Medicina. Universidad Nacional Autónoma de México, Hospital Infantil de México Federico Gómez.
Nutr Hosp. 2023 Jun 21;40(3):511-516. doi: 10.20960/nh.04343.
Introduction: obesity in the pediatric population is a public health problem. The correlation of uric acid and carotid intima media thickness in adults has been demonstrated. Objective: to identify the correlation of uric acid and carotid intima media thickness in adolescents with obesity. Material and methods: an observational, cross-sectional study was carried out. Patients aged ten to 16 years with a diagnosis of obesity were included. Uric acid, lipid profile and carotid intima media thickness were determined. In relation to the statistical analysis, carotid intima media thickness was correlated with uric acid levels through Spearman's correlation coefficient. Results: one hundred and sixty-nine adolescents were included with a median age of 13 years, without predominance of sex. A positive correlation of uric acid with carotid intima media thickness was identified (r = 0.242, p = 0.001). When stratified according to sex, there was no correlation in women (r = -0.187, p = 0.074), while in men it increased (r = 0.36, p = 0.001) and by pubertal stage, pubertal male adolescents had a positive correlation (p = 0.384, p = 0.002). Conclusion: a weak positive correlation was identified between carotid intimal thickness and uric acid in obese adolescents.
儿童肥胖是一个公共卫生问题。成人尿酸与颈动脉内膜中层厚度之间的相关性已得到证实。目的：确定肥胖青少年尿酸与颈动脉内膜中层厚度之间的相关性。材料与方法：进行了一项观察性横断面研究。纳入年龄在10至16岁且诊断为肥胖的患者。测定尿酸、血脂谱和颈动脉内膜中层厚度。关于统计分析，通过Spearman相关系数将颈动脉内膜中层厚度与尿酸水平进行相关性分析。结果：纳入169名青少年，中位年龄为13岁，无性别优势。确定尿酸与颈动脉内膜中层厚度呈正相关（r = 0.242，p = 0.001）。按性别分层时，女性无相关性（r = -0.187，p = 0.074）；而男性相关性增加（r = 0.36，p = 0.001），按青春期阶段分层，青春期男性青少年呈正相关（r = 0.384，p = 0.002）。结论：肥胖青少年颈动脉内膜厚度与尿酸之间存在弱正相关。
