Department of Cardiology.
Department of Hematology, Zhongshan City People's Hospital, Zhongshan City, Guangdong, China.
J Hypertens. 2023 Jul 1;41(7):1152-1158. doi: 10.1097/HJH.0000000000003442. Epub 2023 Apr 19.
The causal relationship between childhood obesity and hypertension in pregnancy remains unclear. To examine the causal association between childhood obesity and hypertension in pregnancy, two-sample Mendelian randomization analysis was applied.
Single-nucleotide polymorphisms (SNPs) associated with childhood obesity were obtained from a published genome-wide association study (GWAS) of 13 848 European individuals. Summary-level data for hypertension in pregnancy were obtained from the FinnGen consortium (11534 cases and 162212 controls). Inverse-variance weighted analysis, weighted-median analysis, and Mendelian randomization-Egger regression were conducted in this Mendelian randomization analysis. Sensitivity analyses were conducted to confirm the accuracy and robustness of our results.
Genetically determined childhood obesity significantly affects hypertension in pregnancy by IVW [odds ratio (OR) = 1.161, 95% confidence interval (CI) 1.086-1.039; P = 9.92 × 10 -6 ] and weighted median (OR = 1.123, 95% CI 1.038-1.214; P = 0.004). These results were validated by multiple sensitivity analyses.
A causal effect between genetically predicted childhood obesity and the risk of hypertension in pregnancy was identified. The prevention of hypertension in pregnancy should be promoted in populations with childhood obesity.
儿童肥胖与妊娠高血压之间的因果关系仍不清楚。为了研究儿童肥胖与妊娠高血压之间的因果关联，采用了两样本孟德尔随机化分析。
从已发表的一项针对 13848 名欧洲个体的全基因组关联研究（GWAS）中获得与儿童肥胖相关的单核苷酸多态性（SNP）。妊娠高血压的汇总水平数据来自芬兰人群遗传研究（FinnGen）联盟（11534 例病例和 162212 例对照）。本孟德尔随机化分析中进行了逆方差加权分析、加权中位数分析和孟德尔随机化-Egger 回归。进行了敏感性分析以确认我们结果的准确性和稳健性。
基于 IVW 的遗传确定的儿童肥胖显著影响妊娠高血压（OR=1.161，95%CI 1.086-1.039；P=9.92×10-6）和加权中位数（OR=1.123，95%CI 1.038-1.214；P=0.004）。这些结果通过多种敏感性分析得到验证。
确定了遗传预测的儿童肥胖与妊娠高血压风险之间存在因果关系。在儿童肥胖人群中应促进妊娠高血压的预防。
