Jacques L, Mathieu D, Bizzini B
Pathol Biol (Paris). 1978 Nov;26(8):495-502.
Experiments were carried out to study in vitro the variations of phagocytic activity of circulating leukocytes from rats which received a thermal injury and were either immunostimulated or not by a single iv injection of C. granulosum. The thermal injury which was applied at about 10 percent of the body surface was of an intermediary type ; it developed towards necrosis before cicatrising on about the 30th day. Phagocytic activity was expressed as the percentage of "active" phagocytes or of those cells which phagocytosed Sta. aureus and S. typhi murium. In not immunostimulated rats, the phagocytic activity was profoundly depressed as a result of the thermal injury ; this was most marked at about 8 days after the thermal injury (close to 38% compared with 80% in control-not-burned-rats). The phagocytic potency or circulating leukocytes from burned and immunostimulated rats corresponded at about the 8th day to that of healthy rats. The reported variations are statistically significant, as assessed by the Student "t" and X2 tests. Our study showed that those rats which were burned in our experimental conditions responded favourably to the immunostimulation. It would be interesting to check whether the use of anaerobic corynebacteria in man could represent an adjunct treatment of those septic complications which are so frequent in severe burns.
进行了实验，以体外研究接受热损伤的大鼠循环白细胞吞噬活性的变化，这些大鼠通过单次静脉注射颗粒丙酸杆菌进行免疫刺激或未进行免疫刺激。约占体表10%的热损伤属于中度类型；在大约第30天愈合前发展为坏死。吞噬活性以“活跃”吞噬细胞或吞噬金黄色葡萄球菌和鼠伤寒沙门氏菌的细胞的百分比表示。在未免疫刺激的大鼠中，热损伤导致吞噬活性显著降低；在热损伤后约8天最为明显（与未烧伤的对照大鼠的80%相比接近38%）。烧伤并免疫刺激的大鼠的循环白细胞吞噬能力在大约第8天与健康大鼠相当。经学生“t”检验和X²检验评估，所报告的变化具有统计学意义。我们的研究表明，在我们的实验条件下烧伤的那些大鼠对免疫刺激反应良好。检查在人类中使用厌氧棒状杆菌是否可以作为严重烧伤中频繁出现的败血症并发症的辅助治疗方法将是很有趣的。
