Shariati Hospital, Department of Urology, Tehran University of Medical Sciences, Tehran, Iran.
Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC Nephrol. 2020 Jan 6;21(1):5. doi: 10.1186/s12882-019-1670-x.
Several factors such as recipient age, BMI, serum cratinine, and positive history of dialysis are important in predicting graft survival among kidney transplant recipients. One factor affecting the transplant outcomes is donors and recipients gender, which is usually ignored.
A total of 1113 kidney transplant recipients were studied in this retrospective cohort study. Several factors were taken into account for graft survival and outcomes such as donors and recipients gender and age in addition to common recipient factors like cratinine, eGFR, BMI, and positive history of dialysis.
The most successful transplant based on donor-recipient gender was observed in male donor to male recipient, and then male donor to female recipient. In female transplant recipients, level of serum cratinine and eGFR, positive dialysis history before transplant, and low donor hemoglobin level can be considered as good prognostic factors recommended for kidney transplant survival.
Our results suggested gender matching for kidney transplant. Only in some exceptional conditions, male donor to female recipient kidney transplant may be successful and female donors to male recipients are not suggested, especially in aged patients with the history of dialysis.
在预测肾移植受者的移植物存活率方面，受体年龄、BMI、血清肌酐和透析阳性史等几个因素很重要。影响移植结果的一个因素是供者和受者的性别，这通常被忽视。
本回顾性队列研究共纳入 1113 例肾移植受者。除了肌酐、eGFR、BMI 和透析阳性史等常见受者因素外，还考虑了供者和受者的性别和年龄等因素，以评估移植物存活率和结果。
根据供受者的性别，最成功的移植是在男性供者与男性受者之间，其次是男性供者与女性受者之间。在女性移植受者中，血清肌酐和 eGFR 水平、移植前透析阳性史以及低供体血红蛋白水平可被视为推荐用于肾移植存活的良好预后因素。
我们的结果表明，性别匹配对肾移植很重要。只有在某些特殊情况下，男性供者向女性受者的肾移植可能成功，而不建议女性供者向男性受者进行移植，尤其是在有透析史的老年患者中。
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