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盐酸凯普拉赞:首次批准。

Keverprazan Hydrochloride: First Approval.

机构信息

Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.

出版信息

Drugs. 2023 May;83(7):639-643. doi: 10.1007/s40265-023-01865-w.

DOI:10.1007/s40265-023-01865-w
PMID:37074491
Abstract

Keverprazan hydrochloride () is a potassium ion competitive acid blocker that is being developed by Jiangsu Carephar Pharmaceuticals for the treatment of acid-related disease. Keverprazan hydrochloride was recently approved in China for the treatment of adults with reflux oesophagitis or duodenal ulcer. This article summarizes the milestones in the development of keverprazan hydrochloride leading to this first approval for reflux oesophagitis and duodenal ulcer.

摘要

盐酸凯普拉嗪()是一种钾离子竞争性酸阻滞剂,由江苏奥赛康药业开发,用于治疗与酸相关的疾病。盐酸凯普拉嗪最近在中国获批用于治疗成人反流性食管炎或十二指肠溃疡。本文总结了盐酸凯普拉嗪开发过程中的重要里程碑,最终使其首次获批用于反流性食管炎和十二指肠溃疡的治疗。

相似文献

1
Keverprazan Hydrochloride: First Approval.盐酸凯普拉赞:首次批准。
Drugs. 2023 May;83(7):639-643. doi: 10.1007/s40265-023-01865-w.
2
Vonoprazan: first global approval.伏诺拉生:全球首次获批
Drugs. 2015 Mar;75(4):439-43. doi: 10.1007/s40265-015-0368-z.
3
The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: a phase III, randomised, double-blind multicentre study.新型钾离子竞争性酸阻滞剂凯维拉唑治疗糜烂性食管炎的疗效和安全性:一项 III 期、随机、双盲、多中心研究。
Aliment Pharmacol Ther. 2022 Jun;55(12):1524-1533. doi: 10.1111/apt.16959. Epub 2022 May 3.
4
Efficacy of keverprazan for duodenal ulcer: A phase II randomized, double-blind, parallel-controlled trial.钾离子竞争性酸阻滞剂治疗十二指肠溃疡的疗效:一项II期随机、双盲、平行对照试验。
J Gastroenterol Hepatol. 2022 Nov;37(11):2060-2066. doi: 10.1111/jgh.16000. Epub 2022 Sep 16.
5
Helicobacter pylori-induced duodenal ulcer frequently coincides with gastro-oesophageal reflux disease.幽门螺杆菌引起的十二指肠溃疡常与胃食管反流病同时出现。
Dig Liver Dis. 2002 Aug;34(8):542-6. doi: 10.1016/s1590-8658(02)80086-x.
6
Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of infection.消化性溃疡和反流性食管炎的发病时间呈反向趋势,与 感染率的降低显著相关。
Ann Med. 2020 Dec;52(8):506-514. doi: 10.1080/07853890.2020.1782461. Epub 2020 Jun 22.
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No protective role of Helicobacter pylori in the pathogenesis of reflux esophagitis in patients with duodenal or benign gastric ulcer in Korea.在韩国,幽门螺杆菌对十二指肠或良性胃溃疡患者反流性食管炎的发病机制无保护作用。
Dig Dis Sci. 2001 Dec;46(12):2724-32. doi: 10.1023/a:1012783630913.
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Omeprazole: a pharmacoeconomic evaluation of its use in duodenal ulcer and reflux oesophagitis.奥美拉唑:对其在十二指肠溃疡和反流性食管炎治疗中应用的药物经济学评价
Pharmacoeconomics. 1993 Jun;3(6):482-510. doi: 10.2165/00019053-199303060-00008.
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A 1 year follow-up study of the consequences of Helicobacter pylori eradication in duodenal ulcer patients: unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastro-oesophageal reflux disease.十二指肠溃疡患者幽门螺杆菌根除后果的1年随访研究:糜烂性食管炎的发生率不变,非糜烂性胃食管反流病的患病率降低。
Eur J Gastroenterol Hepatol. 2004 Apr;16(4):369-74. doi: 10.1097/00042737-200404000-00001.
10
Helicobacter pylori eradication improves pre-existing reflux esophagitis in patients with duodenal ulcer disease.根除幽门螺杆菌可改善十二指肠溃疡病患者已有的反流性食管炎。
Clin Gastroenterol Hepatol. 2004 Jun;2(6):474-9. doi: 10.1016/s1542-3565(04)00165-x.

引用本文的文献

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Research progress of potassium-competitive acid blockers in the treatment of .钾离子竞争性酸阻滞剂在治疗方面的研究进展 。(原文句子不完整,翻译可能不太准确,完整准确的翻译需结合完整原文)
Ann Med. 2025 Dec;57(1):2544886. doi: 10.1080/07853890.2025.2544886. Epub 2025 Aug 12.
2
Advances in Gastroesophageal Reflux Disease Management: Exploring the Role of Potassium-Competitive Acid Blockers and Novel Therapies.胃食管反流病管理的进展:探索钾离子竞争性酸阻滞剂及新型疗法的作用
Pharmaceuticals (Basel). 2025 May 9;18(5):699. doi: 10.3390/ph18050699.
3
Current research status and trends of potassium-competitive acid blockers in the treatment of acid-related diseases: a bibliometric analysis.

本文引用的文献

1
Efficacy of keverprazan for duodenal ulcer: A phase II randomized, double-blind, parallel-controlled trial.钾离子竞争性酸阻滞剂治疗十二指肠溃疡的疗效:一项II期随机、双盲、平行对照试验。
J Gastroenterol Hepatol. 2022 Nov;37(11):2060-2066. doi: 10.1111/jgh.16000. Epub 2022 Sep 16.
2
The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: a phase III, randomised, double-blind multicentre study.新型钾离子竞争性酸阻滞剂凯维拉唑治疗糜烂性食管炎的疗效和安全性:一项 III 期、随机、双盲、多中心研究。
Aliment Pharmacol Ther. 2022 Jun;55(12):1524-1533. doi: 10.1111/apt.16959. Epub 2022 May 3.
3
钾离子竞争性酸阻滞剂治疗酸相关性疾病的研究现状与趋势:一项文献计量学分析
Front Pharmacol. 2025 Jan 7;15:1477633. doi: 10.3389/fphar.2024.1477633. eCollection 2024.
4
A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (X842) and Lansoprazole for the Treatment of Patients With Erosive Esophagitis.一项关于钾离子竞争性酸阻滞剂(X842)与兰索拉唑治疗糜烂性食管炎患者的随机对照试验。
Clin Transl Gastroenterol. 2025 Apr 1;16(4):e00803. doi: 10.14309/ctg.0000000000000803.
5
Potassium-competitive Acid Blockers: Current Clinical Use and Future Developments.钾离子竞争型酸阻断剂:当前临床应用与未来发展。
Curr Gastroenterol Rep. 2024 Nov;26(11):273-293. doi: 10.1007/s11894-024-00939-3. Epub 2024 Aug 15.
6
Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers vs. Proton Pump Inhibitors for Peptic Ulcer with or without Infection: A Systematic Review and Network Meta-Analysis.钾离子竞争性酸阻滞剂与质子泵抑制剂治疗伴或不伴感染的消化性溃疡的疗效和安全性比较:一项系统评价和网状Meta分析
Pharmaceuticals (Basel). 2024 May 28;17(6):698. doi: 10.3390/ph17060698.
KFP-H008 blocks gastric acid secretion through inhibiting H-K-ATPase.
KFP-H008 通过抑制 H-K-ATPase 来阻断胃酸分泌。
Eur J Pharmacol. 2017 Sep 5;810:112-119. doi: 10.1016/j.ejphar.2017.06.020. Epub 2017 Jun 16.