Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, South Carolina SmartState Center for Healthcare Quality, University of South Carolina, Discovery I, Suite 413, 915 Greene Street, 29208, Columbia, SC, USA.
Department of Psychology, Virginia Commonwealth University, 23284, Richmond, VA, PO Box 842018, USA.
AIDS Behav. 2023 Oct;27(10):3508-3514. doi: 10.1007/s10461-023-04066-4. Epub 2023 Apr 19.
Prescription opioid misuse (POM) is a concern in people living with HIV (PLWH). Pain interference is a robust factor, and its influences would occur through anxiety and resilience. Limited POM studies attend to Chinese PLWH. This study examined POM and its underlying psychological mechanism using data of PLWH with pain (n = 116) from a cohort study in Guangxi. The PROCESS macro was employed to examine a hypothesized moderated mediation model among pain interference, resilience, anxiety, and POM. Results showed 10.3% PLWH engaged in past-three-month POM. After controlling for demographics, HIV-related clinical outcomes, and pain severity, anxiety mediated the association between pain interference and POM (β = 0.46, 95% CI = 0.01 to 10.49), and the mediation was moderated by resilience (moderated mediation index = - 0.02, 95% CI = - 0.784 to - 0.001). Chinese PLWH seem to misuse opioids to cope with pain-related anxiety. Resilience appears to offer protection.
处方阿片类药物滥用（POM）是 HIV 感染者（PLWH）关注的问题。疼痛干扰是一个强有力的因素，其影响会通过焦虑和适应力发生。有限的 POM 研究关注中国的 PLWH。本研究使用来自广西队列研究中具有疼痛的 PLWH（n=116）的数据，检验了 POM 及其潜在的心理机制。PROCESS 宏用于检验疼痛干扰、适应力、焦虑和 POM 之间假设的调节中介模型。结果显示，10.3%的 PLWH 在过去三个月中有过 POM。在控制人口统计学、HIV 相关临床结局和疼痛严重程度后，焦虑介导了疼痛干扰与 POM 之间的关联（β=0.46，95%CI=0.01 至 10.49），而适应力调节了这种关联（调节中介指数=-0.02，95%CI=-0.784 至-0.001）。中国的 PLWH 似乎滥用阿片类药物来应对与疼痛相关的焦虑。适应力似乎提供了保护。
