Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China; Health MY (Shenzhen) Technology Co., Ltd, Shenzhen 518060, PR China.
Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China.
Int J Biol Macromol. 2023 Jun 15;240:124495. doi: 10.1016/j.ijbiomac.2023.124495. Epub 2023 Apr 17.
Cotton fabrics (CFs) with persistent and rapid bactericidal capability would be of great significance for daily health protection because CFs are very suitable for the growth and reproduction of microorganisms. Herein, we developed a reactive N-halamine compound, 3-(3-hydroxypropyl diisocyanate)-5,5-dimethylhydantoin (IPDMH), that can be covalently bound to a CF to generate a bactericidal CF after chlorination (CF-DMF-Cl) without damaging its surface morphology. The antibacterial rates of CF-DMF-Cl (0.5 wt% IPDMH) against the gram-negative bacterium Escherichia coli (E. coli) and gram-positive bacterium Staphylococcus aureus (S. aureus) reached 99.99 % and were maintained at 90 % (against E. coli) and 93.5 % (against S. aureus) after 50 laundering cycles. The combination of contact killing and release killing mechanisms by CF-PDM-Cl leads to its rapid and persistent bactericidal activity. In addition, CF-DMF-Cl exhibits adequate biocompatibility, well-maintained mechanical properties, air/water vapor permeability and whiteness. Therefore, the proposed CF-DMF-Cl has great potential applications as a bactericidal CF for use in medical textiles, sportswear, home dressings, and so on.
棉织物（CFs）具有持久和快速的杀菌能力，对于日常健康保护非常重要，因为 CFs 非常适合微生物的生长和繁殖。在此，我们开发了一种反应性 N-卤胺化合物，3-(3-羟丙基二异氰酸酯)-5,5-二甲基海因（IPDMH），它可以通过氯化共价结合到 CF 上生成杀菌 CF（CF-DMF-Cl），而不会破坏其表面形态。CF-DMF-Cl（0.5 wt% IPDMH）对革兰氏阴性菌大肠杆菌（E. coli）和革兰氏阳性菌金黄色葡萄球菌（S. aureus）的抑菌率达到 99.99%，经过 50 次洗涤循环后，对 E. coli 的抑菌率保持在 90%，对 S. aureus 的抑菌率保持在 93.5%。CF-PDM-Cl 通过接触杀灭和释放杀灭机制的结合，使其具有快速持久的杀菌活性。此外，CF-DMF-Cl 表现出足够的生物相容性、良好的机械性能、空气/水蒸气渗透性和白度。因此，所提出的 CF-DMF-Cl 具有作为医用纺织品、运动服装、家居敷料等杀菌 CF 的巨大应用潜力。
